SP 141
- Product Name
- SP 141
- CAS No.
- 1253491-42-7
- Chemical Name
- SP 141
- Synonyms
- SP 141;SP 141;SP141;;6-Methoxy-1-(1-naphthyl)-9H-β-carboline;6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole;6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-;pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141
- CBNumber
- CB23146385
- Molecular Formula
- C22H16N2O
- Formula Weight
- 324.38
- MOL File
- 1253491-42-7.mol
SP 141 Property
- Boiling point:
- 571.2±45.0 °C(Predicted)
- Density
- 1.284±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 15.04±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17003
- Product name
- SP 141
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17003
- Product name
- SP 141
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 17003
- Product name
- SP 141
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 17003
- Product name
- SP 141
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $849
- Updated
- 2024/03/01
- Product number
- 5332
- Product name
- SP141
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $870
- Updated
- 2021/12/16
SP 141 Chemical Properties,Usage,Production
Description
Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.
Uses
SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines, inhibiting xenograft tumor growth in vivo.
storage
Store at +4°C
References
[1]. vassilev lt, vu bt, graves b, et al. in vivo activation of the p53 pathway by small-molecule antagonists of mdm2. science. 2004 feb 6;303(5659):844-8.
[2]. wang w, qin jj, voruganti s, et al. the pyrido[b]indole mdm2 inhibitor sp-141 exerts potent therapeutic effects in breast cancer models. nat commun. 2014 oct 1;5:5086.
[3]. wang w, qin jj, voruganti s, et al. identification of a new class of mdm2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. gastroenterology. 2014 oct;147(4):893-902.e2.
[4]. nag s, qin jj, voruganti s, et al. development and validation of a rapid hplc method for quantitation of sp-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice. biomed chromatogr. 2015 may;29(5):654-63.