ChemicalBook > CAS DataBase List > Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Product Name: Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
CAS No.: 2003260-55-5
Chemical Name: Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
Synonyms: CS-2874;KDM4B-IN-B3;NCGC00244536;KDM4B Inhibitor B3;NCGC00244536 ，E0132;NCGC00244536(Benzamide);KDM4B INHIBITOR COMPOUND B3;NCGC00244536, 10 mM in DMSO;3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide;Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
CBNumber: CB23146688
Molecular Formula: C25H22N2O2
Formula Weight: 382.45
MOL File: 2003260-55-5.mol

Less

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Property

Boiling point:: 646.9±55.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM)
form: A crystalline solid
pka: 4.81±0.40(Predicted)
color: Light yellow to green yellow

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 25mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 10mg
Price: $263
Updated: 2024/03/01

ChemScene

Product number: CS-6877
Product name: NCGC00244536
Purity: 98.02%
Packaging: 5mg
Price: $396
Updated: 2021/12/16

Less

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Chemical Properties,Usage,Production

Uses

NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM.

Biological Activity

NCGC00244536 is a potent KDM4B inhibitor with IC50 of 10 nM.

in vitro

NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC ₅₀ =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4 . NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC ₅₀ s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC ₅₀ s.

in vivo

Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis .

IC 50

KDM4

References

[1] Duan L, et al. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol. 2015 Sep 17;22(9):1185-96. DOI:10.1016/j.chembiol.2015.08.007

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Suppliers

China 67 India 1 United States 8 Global 76

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 3935
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10109
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Chengdu Henghui Pharmaceutical Co., Ltd.

Tel: 86-028-89481236 13540674322 15828370308
Fax: 86-028-89481236
Country: China
ProdList: 96
Advantage: 58

Beijing Minruida Technology Co., Ltd.

Tel: 010-82387566 18001021521;
Fax: 82387566-801
Email: sales@mreda.com.cn
Country: China
ProdList: 10083
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Shanghai Daeyeon Chemicals Co., Ltd

Tel: 021-64478606 +8615900664856
Email: daeyeon001@vip.163.com
Country: China
ProdList: 2062
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.

Tel: 0431-80514535 13634302652
Fax: 0431-88607838
Email: Extension@chemextension.com
Country: CHINA
ProdList: 967
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Shanghai Jiange Chemical Co., Ltd.

Tel: 15921040873
Email: 1434142450@qq.com
Country: CHINA
ProdList: 7649
Advantage: 58

Zhengzhou Edward Biology Co.,Ltd

Tel: 0371-63682289 15538176268
Fax: QQ：1875164801
Email: jacschem@163.com
Country: China
ProdList: 9926
Advantage: 58

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1984
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 3011
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80534350 15044023330
Email: caoy@chemextension.com
Country: China
ProdList: 2016
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 2998
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 18130062233
Email: 3362556465@qq.com
Country: China
ProdList: 8100
Advantage: 58

ChemeGen

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9957
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-025-66113011 18626450290
Email: cb5@aikonchem.com
Country: China
ProdList: 10358
Advantage: 58

Deyang Sino Biotech. Co., LTD

Tel: +86-19182167371 +86-19182167371;
Email: service@synlord.com
Country: China
ProdList: 110
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509; 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 4970
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-13823398 15111215862
Email: 313359644@qq.com
Country: China
ProdList: 4161
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9763
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 14580
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., Ltd.,

Tel: 18915873328 18915873328
Email: 296197970@qq.com
Country: China
ProdList: 11051
Advantage: 58

2003260-55-5, Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-Related Search:

KDM4B INHIBITOR COMPOUND B3

CS-2874

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

NCGC00244536

KDM4B-IN-B3

KDM4B Inhibitor B3

NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536

3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide

NCGC00244536(Benzamide)

NCGC00244536, 10 mM in DMSO

NCGC00244536 ，E0132

2003260-55-5