Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

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Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Product Name: Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
CAS No.: 2003260-55-5
Chemical Name: Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
Synonyms: CS-2874;KDM4B-IN-B3;NCGC00244536;KDM4B Inhibitor B3;NCGC00244536(Benzamide);KDM4B INHIBITOR COMPOUND B3;3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide;Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-;NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536
CBNumber: CB23146688
Molecular Formula: C25H22N2O2
Formula Weight: 382.45
MOL File: 2003260-55-5.mol

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Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Property

Boiling point:: 646.9±55.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM)
form: A crystalline solid
pka: 4.81±0.40(Predicted)
color: Light yellow to green yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 25mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 18478
Product name: NCGC00244536
Packaging: 10mg
Price: $263
Updated: 2024/03/01

ChemScene

Product number: CS-6877
Product name: NCGC00244536
Purity: 98.02%
Packaging: 5mg
Price: $396
Updated: 2021/12/16

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Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Chemical Properties,Usage,Production

Biological Activity

NCGC00244536 is a potent KDM4B inhibitor with IC50 of 10 nM.

in vitro

NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC ₅₀ =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4 . NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC ₅₀ s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC ₅₀ s.

in vivo

Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis .

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2003260-55-5, Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-Related Search:

KDM4B INHIBITOR COMPOUND B3

CS-2874

Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

NCGC00244536

KDM4B-IN-B3

KDM4B Inhibitor B3

NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536

3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide

NCGC00244536(Benzamide)

2003260-55-5