Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
- Product Name
- Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
- CAS No.
- 2003260-55-5
- Chemical Name
- Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
- Synonyms
- CS-2874;KDM4B-IN-B3;NCGC00244536;KDM4B Inhibitor B3;NCGC00244536(Benzamide);KDM4B INHIBITOR COMPOUND B3;3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide;Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-;NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536
- CBNumber
- CB23146688
- Molecular Formula
- C25H22N2O2
- Formula Weight
- 382.45
- MOL File
- 2003260-55-5.mol
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Property
- Boiling point:
- 646.9±55.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM) - form
- A crystalline solid
- pka
- 4.81±0.40(Predicted)
- color
- Light yellow to green yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18478
- Product name
- NCGC00244536
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 18478
- Product name
- NCGC00244536
- Packaging
- 25mg
- Price
- $593
- Updated
- 2024/03/01
- Product number
- 18478
- Product name
- NCGC00244536
- Packaging
- 5mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 18478
- Product name
- NCGC00244536
- Packaging
- 10mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- CS-6877
- Product name
- NCGC00244536
- Purity
- 98.02%
- Packaging
- 1mg
- Price
- $132
- Updated
- 2021/12/16
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Chemical Properties,Usage,Production
Biological Activity
NCGC00244536 is a potent KDM4B inhibitor with IC50 of 10 nM.
in vitro
NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC 50 =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4 . NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC 50 s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC 50 s.
in vivo
Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis .
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Suppliers
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- Country
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