ChemicalBook > CAS DataBase List > KPT-8602
KPT-8602
- Product Name
- KPT-8602
- CAS No.
- 1642300-52-4
- Chemical Name
- KPT-8602
- Synonyms
- CS-2388;ATG-016;ONO-7706;KPT-8602;Eltanexor;CAS:1642300-52-4;KPT-8602 (KPT 8602;Eltanexor (KPT-8602;Eltanexor, 10 mM in DMSO;Eltanexor (KPT-8602) ，S8397
- CBNumber
- CB23151727
- Molecular Formula
- C17H10F6N6O
- Formula Weight
- 428.3
- MOL File
- 1642300-52-4.mol
More
Less
KPT-8602 Property
- Boiling point:
- 574.4±60.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.06±0.50(Predicted)
- color
- Off-white to light yellow
More
Less
More
Less
N-Bromosuccinimide Price
Biorbyt Ltd
- Product number
- orb611488
- Product name
- Eltanexor
- Packaging
- 5mg
- Price
- $430.1
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb611488
- Product name
- Eltanexor
- Packaging
- 50mg
- Price
- $1149.2
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC22589
- Product name
- Eltanexor
- Purity
- >98%
- Packaging
- 50mg
- Price
- $760
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC22589
- Product name
- Eltanexor
- Purity
- >98%
- Packaging
- 5mg
- Price
- $208
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC22589
- Product name
- Eltanexor
- Purity
- >98%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
More
Less
KPT-8602 Chemical Properties,Usage,Production
Uses
(αE)-α-[[3-[3,5-bis(Trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-5-pyrimidineacetamide is an exportin-1 inhibitor with anti-leukemic activity. Exportin-1 mediates nuclear trafficking of proteins. (αE)-α-[[3-[3,5-bis(Trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-5-pyrimidineacetamide can be used to develop treatments for acute lymphoblastic leukemia.
in vivo
KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) shows potent anti-lymphoblastic leukemia activity[1].
| Animal Model: | Female BALB/c mice (model with the JAK3 (M511I) mutation)[1] |
| Dosage: | 15 mg/kg |
| Administration: | Oral gavage; daily for 12 days |
| Result: | Showed a marked reduction in total white blood cell (WBC) counts after 2 days of treatment compared to placebo-treated animals and the WBC counts continued to drop until they reached normal levels (<10,000 cells/μL) by day 12. |
KPT-8602 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
KPT-8602 Suppliers
- Tel
- 025-83697070 13770331960
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16053
- Advantage
- 64
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4769
- Advantage
- 55
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4817
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
- 60
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 9955
- Advantage
- 58
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29661
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13761635123
- Fax
- 1014988033@qq
- sales@linyuepharm.com
- Country
- China
- ProdList
- 5562
- Advantage
- 55
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58