ChemicalBook > CAS DataBase List > KPT-8602
KPT-8602
- Product Name
- KPT-8602
- CAS No.
- 1642300-52-4
- Chemical Name
- KPT-8602
- Synonyms
- CS-2388;ATG-016;ONO-7706;KPT-8602;Eltanexor;CAS:1642300-52-4;KPT-8602 (KPT 8602;Eltanexor (KPT-8602;Eltanexor, 10 mM in DMSO;Eltanexor (KPT-8602) ，S8397
- CBNumber
- CB23151727
- Molecular Formula
- C17H10F6N6O
- Formula Weight
- 428.3
- MOL File
- 1642300-52-4.mol
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KPT-8602 Property
- Boiling point:
- 574.4±60.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.06±0.50(Predicted)
- color
- Off-white to light yellow
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N-Bromosuccinimide Price
Biorbyt Ltd
- Product number
- orb611488
- Product name
- Eltanexor
- Packaging
- 5mg
- Price
- $430.1
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb611488
- Product name
- Eltanexor
- Packaging
- 50mg
- Price
- $1149.2
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC22589
- Product name
- Eltanexor
- Purity
- >98%
- Packaging
- 5mg
- Price
- $208
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC22589
- Product name
- Eltanexor
- Purity
- >98%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC22589
- Product name
- Eltanexor
- Purity
- >98%
- Packaging
- 50mg
- Price
- $760
- Updated
- 2021/12/16
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KPT-8602 Chemical Properties,Usage,Production
Uses
(αE)?-α-?[[3-?[3,?5-?bis(Trifluoromethyl)?phenyl]?-?1H-?1,?2,?4-?triazol-?1-?yl]?methylene]?-?5-pyrimidineacetamide is an exportin-1 inhibitor with anti-leukemic activity. Exportin-1 mediates nuclear trafficking of proteins. (αE)?-α-?[[3-?[3,?5-?bis(Trifluoromethyl)?phenyl]?-?1H-?1,?2,?4-?triazol-?1-?yl]?methylene]?-?5-pyrimidineacetamide can be used to develop treatments for acute lymphoblastic leukemia.
in vivo
KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) shows potent anti-lymphoblastic leukemia activity[1].
| Animal Model: | Female BALB/c mice (model with the JAK3 (M511I) mutation)[1] |
| Dosage: | 15 mg/kg |
| Administration: | Oral gavage; daily for 12 days |
| Result: | Showed a marked reduction in total white blood cell (WBC) counts after 2 days of treatment compared to placebo-treated animals and the WBC counts continued to drop until they reached normal levels (<10,000 cells/μL) by day 12. |
KPT-8602 Preparation Products And Raw materials
Raw materials
Preparation Products
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