galacto-Dapagliflozin
- Product Name
- galacto-Dapagliflozin
- CAS No.
- 1408245-02-2
- Chemical Name
- galacto-Dapagliflozin
- Synonyms
- galacto-Dapagliflozin;JVHXJTBJCFBINQ-IFLJBQAJSA-N;Dapagliflozin Galacto Isomer;(1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-galactitol;D-Galactitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-;(2S,3R,4R,5R,6R)-2-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
- CBNumber
- CB23152618
- Molecular Formula
- C21H25ClO6
- Formula Weight
- 408.87
- MOL File
- 1408245-02-2.mol
galacto-Dapagliflozin Property
- storage temp.
- Store at -20°C
- solubility
- ≤30mg/ml in DMSO;50mg/ml in dimethyl formamide
- form
- crystalline solid
N-Bromosuccinimide Price
- Product number
- 15952
- Product name
- galacto-Dapagliflozin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 15952
- Product name
- galacto-Dapagliflozin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $149
- Updated
- 2024/03/01
- Product number
- 15952
- Product name
- galacto-Dapagliflozin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $241
- Updated
- 2024/03/01
- Product number
- 15952
- Product name
- galacto-Dapagliflozin
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $1068
- Updated
- 2024/03/01
- Product number
- 5837EH
- Product name
- (2S,3R,4R,5R,6R)-2-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
- Packaging
- 50mg
- Price
- $1288
- Updated
- 2021/12/16
galacto-Dapagliflozin Chemical Properties,Usage,Production
Uses
Galacto-dapagliflozin is a selective inhibitor for hSGLT2 with Ki of 25 nM[1].
Biological Activity
ki = 2 nmgalacto-dapagliflozin is a potent inhibitor of human sglt2.renal glucose transport is mediated by sodium-glucose cotransporters (sglt) 1 and 2. in humans, sglt2 is responsible for the majority of glucose reabsorption in the kidney.
in vitro
it was found that galacto-dapagliflozin was a selective inhibitor of hsglt2, but was less potent than dapagliflozin for both transporters. both phlorizin and galacto-dapagliflozin rapidly dissociated from sglt2, while dapagliflozin and fluoro-dapagliflozin dissociated from hsglt2 at a rate 10-fold slower. dapagliflozin, fluoro-dapagliflozin, and galacto-dapagliflozin dissociated quickly from hsglt1, and phlorizin readily exchanged with dapagliflozin bound to hsglt1 [1].
in vivo
male db/db mice were administered dapagliflozin for 12 weeks. results showed that administration of dapagliflozin could ameliorate hyperglycemia, β-cell damage and albuminuria in db/db mice. serum creatinine, creatinine clearance and blood pressure were not affected by administration of dapagliflozin. dapagliflozin treatment was able to decrease macrophage infiltration in the kidney of db/db mice [2].
IC 50
hSGLT2: 25 nM (Ki); hSGLT1: 25000 nM (Ki)
References
[1] hummel, c. s.,lu, c.,liu, j., et al. structural selectivity of human sglt inhibitors. american journal of physiology.cell physiology 302(2), c373-c382 (2012).
[2] terami n et al. long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. plos one. 2014 jun 24;9(6):e100777.
[3] merovci a et al. dapagliflozin lowers plasma glucose concentration and improves β-cell function. j clin endocrinol metab. 2015 may;100(5):1927-32.
galacto-Dapagliflozin Preparation Products And Raw materials
Raw materials
Preparation Products
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