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Sp-8-bromo-Cyclic AMPS (sodium salt)

Product Name
Sp-8-bromo-Cyclic AMPS (sodium salt)
CAS No.
1573115-90-8
Chemical Name
Sp-8-bromo-Cyclic AMPS (sodium salt)
Synonyms
Sp-8-bromo-Cyclic AMPS (sodium salt)
CBNumber
CB23152744
Molecular Formula
C10H12BrN5NaO5PS
Formula Weight
448.16
MOL File
1573115-90-8.mol
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Sp-8-bromo-Cyclic AMPS (sodium salt) Property

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.5 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16002
Product name
Sp-8-bromo-Cyclic AMPS (sodium salt)
Purity
≥98%
Packaging
500μg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
16002
Product name
Sp-8-bromo-Cyclic AMPS (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$222
Updated
2024/03/01
Cayman Chemical
Product number
16002
Product name
Sp-8-bromo-Cyclic AMPS (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$750
Updated
2024/03/01
TRC
Product number
B679390
Product name
8-Bromoadenosine3'',5''-CyclicMonophosphothioateSp-IsomerSodiumSalt
Packaging
2.5mg
Price
$1400
Updated
2021/12/16
TRC
Product number
B679390
Product name
8-Bromoadenosine3'',5''-CyclicMonophosphothioateSp-IsomerSodiumSalt
Packaging
1mg
Price
$725
Updated
2021/12/16
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Sp-8-bromo-Cyclic AMPS (sodium salt) Chemical Properties,Usage,Production

Description

Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.1,2 This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP and Sp-cAMPS . Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5 μM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.3,4

Uses

8-Bromoadenosine 3',5'-Cyclic Monophosphothioate Sp-Isomer Sodium Salt is an activator of cAMP-dependent PKA.

References

1. Yokozaki, H., Tortora, G., Pepe, S., et al. Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells Cancer Res. 52(9),2504-2508(1992).
2. Dostmann, W.R., Taylor, S.S., Genieser, H.G., et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates J. Biol. Chem. 265(18),10484-10491(1990).
3. Schwede, F., Maronde, F., Genieser, H., et al. Cyclic nucleotide analogs as biochemical tools and prospective drugs Pharmacol. Ther. 87(2),199-226(2000).
4. Schaap, P., van Ments-Cohen, M., Soede, R.D., et al. Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium J. Biol. Chem. 268(9),6323-6331(1993).

Sp-8-bromo-Cyclic AMPS (sodium salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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Sp-8-bromo-Cyclic AMPS (sodium salt) Suppliers

Canada 1 China 6 United States 3 Global 10
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
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BOC Sciences
Tel
16314854226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
9713
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1573115-90-8, Sp-8-bromo-Cyclic AMPS (sodium salt)Related Search:

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT HYDRATE Rp-8-bromo-Cyclic AMPS (sodium salt)

  • Sp-8-bromo-Cyclic AMPS (sodium salt)
  • 1573115-90-8