ER-000444793
- Product Name
- ER-000444793
- CAS No.
- 792957-74-5
- Chemical Name
- ER-000444793
- Synonyms
- ER-000444793;ER-000444793 (ER000444793);N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide;4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-;Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793
- CBNumber
- CB23155149
- Molecular Formula
- C23H18N2O2
- Formula Weight
- 354.4
- MOL File
- 792957-74-5.mol
ER-000444793 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (282.17 mM)
N-Bromosuccinimide Price
- Product number
- CS-7582
- Product name
- ER-000444793
- Purity
- >98.0%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-7582
- Product name
- ER-000444793
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-7582
- Product name
- ER-000444793
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $660
- Updated
- 2021/12/16
- Product number
- CS-7582
- Product name
- ER-000444793
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $2340
- Updated
- 2021/12/16
- Product number
- CS-7582
- Product name
- ER-000444793
- Purity
- >98.0%
- Packaging
- 100mg
- Price
- $3540
- Updated
- 2021/12/16
ER-000444793 Chemical Properties,Usage,Production
Biological Activity
ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. It inhibits mPTP with IC50 of 2.8 μM.
in vitro
ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. It potently and dose-dependently inhibits Ca 2+ -induced mPT. It binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC 50 =23 nM and SfA IC 50 = 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled -CsA from rhCypD protein. Together, these data suggest the mechanism of it in delaying mPT is independent of CypD functional inhibition.
target
IC50: 2.8 μM (mPTP)
ER-000444793 Preparation Products And Raw materials
Raw materials
Preparation Products
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