Trofinetide

Product Name: Trofinetide
CAS No.: 853400-76-7
Chemical Name: Trofinetide
Synonyms: Trofinetide;prolyl-;NNZ-2566;Trofinetide (>90%);Trofinetide(NNZ2566);Glutamic acid, glycyl-TROFINETIDE; NNZ2566 ;NNZ 2566; NNZ-2566;L-Glutamic acid, glycyl-2-methyl-L-prolyl-;Trofinetide,NNZ 2566,NNZ2566,Inhibitor,inhibit;(S)-2-((S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carboxamido)pentanedioic acid
CBNumber: CB23159899
Molecular Formula: C13H21N3O6
Formula Weight: 315.32
MOL File: 853400-76-7.mol

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Trofinetide Property

Melting point:: 144 °C
Boiling point:: 655.4±55.0 °C(Predicted)
Density: 1.377±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
pka: 3.51±0.10(Predicted)
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C13H21N3O6/c1-13(5-2-6-16(13)9(17)7-14)12(22)15-8(11(20)21)3-4-10(18)19/h8H,2-7,14H2,1H3,(H,15,22)(H,18,19)(H,20,21)/t8-,13-/m0/s1
InChIKey: BUSXWGRAOZQTEY-SDBXPKJASA-N
SMILES: C(O)(=O)[C@H](CCC(O)=O)NC(=O)[C@]1(C)CCCN1C(=O)CN

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: T892525
Product name: Trofinetide
Packaging: 5mg
Price: $2310
Updated: 2021/12/16

DC Chemicals

Product number: DC11385
Product name: Trofinetide(NNZ2566)
Purity: >98%
Packaging: 250mg
Price: $1100
Updated: 2021/12/16

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Trofinetide Chemical Properties,Usage,Production

Uses

Trofinetide is a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), that has shown to be neuroprotective in animal models of brain injury.

in vivo

Trofinetide (NNZ-2566) suppresses penetrating ballistic-like brain injury (PBBI) induced inflammatory cell infiltration at 3 days following PBBI as compare to vehicle treatment. Trofinetide treatment significantly reduces the elevation of IL-6 (79%), E-selectin (81%), IL-1β (76%) and TNF-α (72%) mRNA levels in the injured hemisphere at 12 h post-PBBI, with maximal inhibition occurring between 12 h and 24 h. Trofinetide treatment does not affect the PBBI-induced up-regulation of IL-6 expression at any time point, but does produce significant reductions in the injury-induced up-regulation of IL-1β, INF-γ, and TNF-α expression. Trofinetide treatment suppresses IL-1β expression in the injured brain hemisphere for up to 7 days post-PBBI^[1]. The high doses of Trofinetide (NNZ-2566) (10 and 100 mg/kg bolus followed by continuous infusion) attenuate non-convulsive seizure (NCS) occurring beyond 2 h after permanent middle cerebral artery occlusion (pMCAo). All doses of Trofinetide completely suppress the delayed occurrence of NCS as compare with the vehicle-treated animals^[2].

Trofinetide Preparation Products And Raw materials

Raw materials

Preparation Products

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Trofinetide Suppliers

China 79 United States 2 Global 81

SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD

Tel: 0838-2809458 13350585791
Email: pharm@biots.cn
Country: China
ProdList: 680
Advantage: 58

Chengdu Yuyang High-tech Development Co., Ltd.

Tel: 0086-13852538605 13308012069
Email: 13308012069@189.cn
Country: China
ProdList: 38
Advantage: 58

Jiangsu Magic Biotechnology Co., Ltd

Tel: 13921770081
Email: svp01@magicbiotech.cn
Country: China
ProdList: 500
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 19353112242
Email: 1816280386@qq.com
Country: China
ProdList: 8045
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 15397062932
Email: sales1@gotopbio.com
Country: China
ProdList: 2982
Advantage: 58

Wuhan Chuangshuo Chemical Technology Co., Ltd

Tel: 180-62205282 18062205282
Email: turbo_cq@163.com
Country: China
ProdList: 34
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16059
Advantage: 64

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

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View Lastest Price from Trofinetide manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: Trofinetide
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-22

853400-76-7, TrofinetideRelated Search:

Trofinetide(NNZ2566)

TROFINETIDE; NNZ2566 ;NNZ 2566; NNZ-2566

NNZ-2566

L-Glutamic acid, glycyl-2-methyl-L-prolyl-

Trofinetide

Trofinetide,NNZ 2566,NNZ2566,Inhibitor,inhibit

Glutamic acid, glycyl-&#8203

prolyl-

(S)-2-((S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carboxamido)pentanedioic acid

Trofinetide (>90%)

(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid

(S)-2-((S)-1-(2-Aminoacetyl)-2-methylpyrrolidine-2-carboxcarboxamido)pentanedioic acid

853400-76-7

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