Mavacamten

Product Name: Mavacamten
CAS No.: 1642288-47-8
Chemical Name: Mavacamten
Synonyms: YMK-461;MYK-461 (SAR-439152);MYK-461;SAR439152;Mawakatan;SAR-439152;SAR 439152;Mavacamten;Mavacampten;Mava Kaitai
CBNumber: CB23170382
Molecular Formula: C15H19N3O2
Formula Weight: 273.33
MOL File: 1642288-47-8.mol

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Mavacamten Property

Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
solubility: insoluble in H2O; ≥11.32 mg/mL in EtOH with ultrasonic; ≥13.65 mg/mL in DMSO
form: solid
pka: 8.83±0.40(Predicted)
color: White to off-white
InChI: InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
InChIKey: RLCLASQCAPXVLM-NSHDSACASA-N
SMILES: C1(=O)NC(N[C@H](C2=CC=CC=C2)C)=CC(=O)N1C(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19216
Product name: MYK-461
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 19216
Product name: MYK-461
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 19216
Product name: MYK-461
Purity: ≥98%
Packaging: 10mg
Price: $270
Updated: 2024/03/01

ApexBio Technology

Product number: A8720
Product name: MYK-461
Packaging: 10mM(in 1mL DMSO)
Price: $310
Updated: 2021/12/16

ChemScene

Product number: CS-0031211
Product name: Mavacamten
Purity: 99.94%
Packaging: 25mg
Price: $330
Updated: 2021/12/16

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Mavacamten Chemical Properties,Usage,Production

Description

Mavacamten（MYK-461）is a first-in-class allosteric inhibitor of cardiac myosin that promises to provide clinicians with targeted therapy for these patients. It is a mechanistically novel small molecule that acts on the sarcolemma to specifically inhibit contractility and has been proposed as a treatment for HCM.

Uses

MYK-461 is a drug used to treat obstructive hypertrophic cardiomyopathy as a cardiac myosin inhibitor. Mavacamten is used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy. It is used to treat symptomatic obstructive hypertrophic cardiomyopathy (HCM).

Application

Mavacamten (trade name Camzyos) is a small molecule cardiac myosin modulator indicated for the treatment of adult patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). oHCM is a monogenic cardiovascular disease caused by mutations in sarcomeric proteins, specifically myosin, that may affect up to 1 in 200 people.

Mechanism of action

Mavacamten is thought to work by reducing cardiac muscle contractility by inhibiting excessive myosin-actin cross-bridge formation that results in hypercontractility, left ventricular hypertrophy and reduced compliance. In clinical and preclinical studies, it has consistently reduced biomarkers of cardiac wall stress, lessened excessive cardiac contractility, and increased diastolic compliance.

Side effects

Common side effects of Mavacamten include: Dizziness, fainting, Incidence not known, Chest pain or tightness, decreased urine output, dilated neck veins, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, unusual tiredness or weakness and weight gain.

Synthesis

Using isopropylamine (8.1) as the starting material, urea 8.2 can be obtained by treatment with trimethylsilyl isocyanate in a yield of 58% (Figure 2.3). Cyclization with dimethyl malonate can give the barbituric acid derivative 8.3 in a yield of 50%. The introduction of the chiral amine side chain is carried out in two steps. First, chlorination is carried out using pure phosphorus oxychloride (POCl3) and triethylbenzylammonium chloride (TEBAC) to obtain chloride 8.4 in a yield of 40%, and then it is treated with (S)-α-methylbenzylamine (8.5) to obtain white solid Mavacamten (8) in a yield of 69%.

Drug interactions

Mavacamten has a variable terminal t1/2 that depends on CYP2C19 metabolic status. Mavacamten's terminal half-life is 6-9 days in CYP2C19 normal metabolizers (NMs), which is prolonged in CYP2C19 poor metabolizers (PMs) to 23 days.

Mavacamten Preparation Products And Raw materials

Raw materials

Preparation Products

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Mavacamten Suppliers

China 211 India 3 United States 7 USA 1 Global 222

Cangzhou Kangrui Medical Technology Co., LTD

Tel: 18632776803
Email: 355803330@qq.com
Country: China
ProdList: 630
Advantage: 58

Shanghai Tube Pharmaceutical Co., Ltd.

Tel: 021-54338626 18017892860
Fax: 021-54338626
Email: sales@tubepharm.com
Country: China
ProdList: 2572
Advantage: 58

Changzhou Yongfeng Biomedicine Co. Ltd.

Tel: 15006117673
Fax: 2973592490@.com
Email: 2973592490@qq.com
Country: China
ProdList: 299
Advantage: 58

Chengdu Dorher Pharmaceutical CO.,Ltd

Tel: 028-64259743; 19983537320
Email: bd-focus@focuspharm.com
Country: China
ProdList: 682
Advantage: 58

Allikang Pharmaceutical Co., LTD

Tel: 0573-87390950 13806705416
Email: wzj@alicornpharma.com
Country: China
ProdList: 57
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509; 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 4970
Advantage: 58

Shandong Jinhu Chemical Co., Ltd.

Tel: 18653796880
Email: sdjhhx@163.com
Country: China
ProdList: 33
Advantage: 58

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 512-62857507
Email: sales@sinorarechem.com
Country: China
ProdList: 697
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

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View Lastest Price from Mavacamten manufacturers

Wuhan Biocar Pharmacy CO.,Ltd.

Product: Mavacamten 1642288-47-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 500kg
Release date: 2025-03-04

Jinan Million Pharmaceutical Co., Ltd

Product: Mavacamten 1642288-47-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99.82%
Supply Ability: 1000g
Release date: 2024-10-29

Jinan Jianfeng Chemical Co., Ltd

Product: Mavacamten MYK-461 1642288-47-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-06-17

1642288-47-8, MavacamtenRelated Search:

7-Diethylamino-4-methylcoumarin

MYK-461 (SAR-439152)

SAR 439152

SAR439152

SAR-439152

SAR-439152; SAR 439152; SAR439152; MYK-461; MYK 461; MYK461; MAVACAMTEN

MYK-461 - Mavacamten | SAR439152

Mavacamten (MYK-461

2,4(1H,3H)-Pyrimidinedione, 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-

6-([(1S)-1-phenylethyl]amino)-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Mavacamten (SAR-439152

YMK-461

MYK-461

6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione

Mavacamten

Mavacamten MYK461 (S)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione

(S)-3-Isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione

3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-2,4(1H,3H)-pyrimidinedione

Mavacampten

Mawakatan

Mava Kaitai

Anamorelin Impurity 36

Mavacamten, 10 mM in DMSO

1642288-47-8

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