Mavacamten

Product Name: Mavacamten
CAS No.: 1642288-47-8
Chemical Name: Mavacamten
Synonyms: YMK-461;MYK-461 (SAR-439152);MYK-461;SAR439152;Mawakatan;SAR-439152;SAR 439152;Mavacamten;Mavacampten;Mava Kaitai
CBNumber: CB23170382
Molecular Formula: C15H19N3O2
Formula Weight: 273.33
MOL File: 1642288-47-8.mol

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Mavacamten Property

Density: 1.19±0.1 g/cm3(Predicted)
solubility: insoluble in H2O; ≥11.32 mg/mL in EtOH with ultrasonic; ≥13.65 mg/mL in DMSO
form: solid
pka: 8.83±0.40(Predicted)
color: White to off-white
InChI: InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
InChIKey: RLCLASQCAPXVLM-NSHDSACASA-N
SMILES: C1(=O)NC(N[C@H](C2=CC=CC=C2)C)=CC(=O)N1C(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19216
Product name: MYK-461
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 19216
Product name: MYK-461
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 19216
Product name: MYK-461
Purity: ≥98%
Packaging: 10mg
Price: $270
Updated: 2024/03/01

ApexBio Technology

Product number: A8720
Product name: MYK-461
Packaging: 10mM(in 1mL DMSO)
Price: $310
Updated: 2021/12/16

ChemScene

Product number: CS-0031211
Product name: Mavacamten
Purity: 99.94%
Packaging: 25mg
Price: $330
Updated: 2021/12/16

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Mavacamten Chemical Properties,Usage,Production

Description

Mavacamten（MYK-461）is a first-in-class allosteric inhibitor of cardiac myosin that promises to provide clinicians with targeted therapy for these patients. It is a mechanistically novel small molecule that acts on the sarcolemma to specifically inhibit contractility and has been proposed as a treatment for HCM.

Uses

MYK-461 is a drug used to treat obstructive hypertrophic cardiomyopathy as a cardiac myosin inhibitor. Mavacamten is used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy. It is used to treat symptomatic obstructive hypertrophic cardiomyopathy (HCM).

Mechanism of action

Mavacamten is thought to work by reducing cardiac muscle contractility by inhibiting excessive myosin-actin cross-bridge formation that results in hypercontractility, left ventricular hypertrophy and reduced compliance. In clinical and preclinical studies, it has consistently reduced biomarkers of cardiac wall stress, lessened excessive cardiac contractility, and increased diastolic compliance.

Side effects

Common side effects include:Dizziness, fainting, Incidence not known, Chest pain or tightness, decreased urine output, dilated neck veins, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, unusual tiredness or weakness and weight gain.

Mavacamten Preparation Products And Raw materials

Raw materials

Preparation Products

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Mavacamten Suppliers

China 171 India 3 United States 7 USA 1 Global 182

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32080
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38470
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

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View Lastest Price from Mavacamten manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: MYK-461 (SAR-439152) 1642288-47-8
Price: US $0.00-0.00/g
Min. Order: 10000g
Purity: 99% HPLC
Supply Ability: 1000kg
Release date: 2024-09-12

Jinan Million Pharmaceutical Co., Ltd

Product: Mavacamten 1642288-47-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99.82%
Supply Ability: 1000g
Release date: 2024-10-29

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Mavacamten 1642288-47-8
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-19

1642288-47-8, MavacamtenRelated Search:

7-Diethylamino-4-methylcoumarin

MYK-461 (SAR-439152)

SAR 439152

SAR439152

SAR-439152

SAR-439152; SAR 439152; SAR439152; MYK-461; MYK 461; MYK461; MAVACAMTEN

MYK-461 - Mavacamten | SAR439152

Mavacamten (MYK-461

2,4(1H,3H)-Pyrimidinedione, 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-

6-([(1S)-1-phenylethyl]amino)-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Mavacamten (SAR-439152

YMK-461

MYK-461

6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione

Mavacamten

Mavacamten MYK461 (S)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione

(S)-3-Isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione

3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-2,4(1H,3H)-pyrimidinedione

Mavacampten

Mawakatan

Mava Kaitai

Anamorelin Impurity 36

1642288-47-8

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