WAY-267464 dihydrochloride
- Product Name
- WAY-267464 dihydrochloride
- CAS No.
- 1432043-31-6
- Chemical Name
- WAY-267464 dihydrochloride
- Synonyms
- WAY267464 HCl;WAY-267464 hydrochloride;WAY-267464 dihydrochloride >=98% (HPLC)
- CBNumber
- CB23175796
- Molecular Formula
- C32H36ClN7O4
- Formula Weight
- 618.14
- MOL File
- 1432043-31-6.mol
WAY-267464 dihydrochloride Property
- storage temp.
- 2-8°C
- solubility
- Soluble to 80 mM in DMSO and to 5 mM in water
- form
- Powder
- color
- white to beige
- Water Solubility
- H2O: 2mg/mL, clear
N-Bromosuccinimide Price
- Product number
- W498660
- Product name
- WAY267464Dihydrochloride
- Packaging
- 10mg
- Price
- $255
- Updated
- 2021/12/16
WAY-267464 dihydrochloride Chemical Properties,Usage,Production
Uses
WAY 267464 Dihydrochloride is an oxytocin receptor agonist.
Biological Activity
WAY-267464 is a non-peptide drug with a novel mechanism of action (MOA) to tre at psychosis and schizophrenia.', 'WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist (EC50 = 61-881 nM; Ki = 58-978 nM) that, unlike oxytocin (OT), displays antagonist instead of agonist activity toward vasopressin V1a receptor/V1aR (IC50 = 613 nM; Ki = 27-113 nM). WAY-267464 exhibits OT-like anxiolytic effects in assays measuring both behavioral (33% increase in punished crossing by 10 mg/mL ip or 10 μg/mouse icv in four-plate tests; 75% increased open quadrants stay by 3 μg/mouse icv in elevated zero maze) and autonomic (47% higher stress-induced hyperthermia by 10 μg/mouse icv) parameters of the anxiety response. Similar to the antipsychotic-like effects reported for OT, WAY-267464 also reverses disruption in prepulse inhibition of the acoustic startle reflex induced by either MK-801 or amphetamine. Unlike OT, WAY-267464 does not affect immobility in mouse tail suspension test.
storage
Store at -20°C
WAY-267464 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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