7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
- Product Name
- 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
- CAS No.
- 440122-66-7
- Chemical Name
- 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
- Synonyms
- WAY 200070;WAY200070;WAY 200070;7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol;5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-;7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol;7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol;Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit
- CBNumber
- CB22518907
- Molecular Formula
- C13H8BrNO3
- Formula Weight
- 306.11
- MOL File
- 440122-66-7.mol
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Property
- Boiling point:
- 463.6±35.0 °C(Predicted)
- Density
- 1.720±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: ≥20mg/mL
- form
- solid
- pka
- 7.26±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- W1520
- Product name
- WAY-200070
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- W1520
- Product name
- WAY-200070
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $441
- Updated
- 2024/03/01
- Product number
- J67375
- Product name
- WAY-200070
- Packaging
- 10mg
- Price
- $204
- Updated
- 2023/06/20
- Product number
- 23323
- Product name
- WAY-200070
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 23323
- Product name
- WAY-200070
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $134
- Updated
- 2024/03/01
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Chemical Properties,Usage,Production
Uses
WAY 200070 is an aryl diphenolic azole and a selective ERβ agonist. This compound is suitable for estrogen receptor signaling research.
Biological Activity
WAY-200070 is a selective estrogen receptor agonist with IC50 of 2.3 nM.
in vivo
Administration of WAY-200070 (30 mg/kg sc) causes nuclear translocation of ERRβ receptors in WT mice. Administration of it produces a delayed 50% increase in dopamine in the striatum of wild type mice. It reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070 , shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.
< /div>
target
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol manufacturers
- Product
- WAY-200070 440122-66-7
- Price
- US $100.00/g
- Min. Order
- 1mg
- Purity
- 99%
- Supply Ability
- 100g 10kgs
- Release date
- 2021-12-21
- Product
- WAY 200070 440122-66-7
- Price
- US $1300.00-11000.00/gram
- Min. Order
- 10gram
- Purity
- 99%
- Supply Ability
- 2 tons
- Release date
- 2022-10-31