WAY 181187

Product Name: WAY 181187
CAS No.: 554403-49-5
Chemical Name: WAY 181187
Synonyms: SAX-187;WAY 181187;WAY181187 HCl;WAY-181187(SAX-187);WAY 181187|||WAY181187;SAX-187, 10 mM in DMSO;WAY181187 hydrochloride;WAY181187.HCl(WAY-181,187);SAX-187;WAY 181187;WAY-181187(SAX-187);WAY181187 HYDROCHLORIDE;1H-Indole-3-ethanamine, 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-
CBNumber: CB92628524
Molecular Formula: C15H13ClN4O2S2
Formula Weight: 380.87
MOL File: 554403-49-5.mol

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WAY 181187 Property

Density: 1.67±0.1 g/cm3(Predicted)
solubility: DMSO: Soluble: =10 mg/ml
form: Solid
pka: 9.30±0.10(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC9668
Product name: WAY181187.HCl（WAY-181,187）
Purity: >98%
Packaging: 100mg
Price: $500
Updated: 2021/12/16

DC Chemicals

Product number: DC9668
Product name: WAY181187.HCl（WAY-181,187）
Purity: >98%
Packaging: 250mg
Price: $900
Updated: 2021/12/16

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WAY 181187 Chemical Properties,Usage,Production

Uses

WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].

in vivo

Acute administration of WAY-181187 (3-30 mg/kg, s.c.) significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 (30 mg/kg, s.c.) produces modest yet significant decreases in cortical dopamine and 5-HT levels^[1].

Animal Model:	Adult male Sprague-Dawley rats weighing 280–350 g^[1]
Dosage:	3, 10, or 30 mg/kg
Administration:	Acute dministered by s.c.
Result:	Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.

IC 50

5-HT₆ Receptor: 2.2 nM (Ki); 5-HT₆ Receptor: 6.6 nM (EC₅₀)

References

[1] Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. DOI:10.1038/sj.npp.1301503

[2] Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. DOI:10.1016/j.ejphar.2011.04.028
[3] DEREK C. COLE. Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist[J]. Journal of Medicinal Chemistry, 2007, 50 23: 5535-5538. DOI: 10.1021/jm070521y

[4] GREGORY V CARR I L Lee E Schechter. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats.[J]. Psychopharmacology, 2011, 213 2-3: 499-507. DOI: 10.1007/s00213-010-1798-7

WAY 181187 Preparation Products And Raw materials

Raw materials

Preparation Products

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WAY 181187 Suppliers

China 40 United States 3 Global 43

Bide Pharmatech Ltd.

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554403-49-5, WAY 181187Related Search:

MAY-262611 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester

WAY 181187

SAX-187

WAY181187.HCl(WAY-181,187)

WAY-181187(SAX-187)

WAY181187 hydrochloride

WAY181187 HCl

SAX-187;WAY 181187;WAY-181187(SAX-187);WAY181187 HYDROCHLORIDE

1H-Indole-3-ethanamine, 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-

related,WAY-181187,Fyn,Serotonin Receptor,5-hydroxytryptamine Receptor,Inhibitor,inhibit,5-HT6,cAMP,OCD,SAX187,disorders,SAX 187,ERK1/2,5-HT Receptor,anxiety

WAY 181187|||WAY181187

2-[1-({6-chloroimidazo[2,1-b][1,3]thiazol-5-yl}sulfonyl)-1H-indol-3-yl]ethan-1-amine

SAX-187, 10 mM in DMSO

2-(1-((6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl)-1H-indol-3-yl)ethan-1-amine

554403-49-5