ChemicalBook > CAS DataBase List > WAY-151932
WAY-151932
- Product Name
- WAY-151932
- CAS No.
- 220460-92-4
- Chemical Name
- WAY-151932
- Synonyms
- VNA-932;WAY-151932;WAY-VNA 932;WAY151932,WAY 151932;Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl-
- CBNumber
- CB23175600
- Molecular Formula
- C23H19ClN4O
- Formula Weight
- 402.88
- MOL File
- 220460-92-4.mol
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WAY-151932 Property
- Boiling point:
- 630.6±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 0.04±0.12(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-6661
- Product name
- WAY-151932
- Packaging
- 1mg
- Price
- $550
- Updated
- 2021/12/16
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WAY-151932 Chemical Properties,Usage,Production
Biological Activity
WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively.
in vitro
WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV 2 receptors in a dose-dependent manner with an EC 50 of 0.74±0.07 nM.
in vivo
Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED 50 =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.
target
IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)
WAY-151932 Preparation Products And Raw materials
Raw materials
Preparation Products
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WAY-151932 Suppliers
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