WAY-151932

Product Name: WAY-151932
CAS No.: 220460-92-4
Chemical Name: WAY-151932
Synonyms: VNA-932;WAY-151932;WAY-VNA 932;VNA-932 (WAY-151932);WAY151932,WAY 151932;Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl-
CBNumber: CB23175600
Molecular Formula: C23H19ClN4O
Formula Weight: 402.88
MOL File: 220460-92-4.mol

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WAY-151932 Property

Boiling point:: 630.6±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 0.04±0.12(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6661
Product name: WAY-151932
Packaging: 1mg
Price: $550
Updated: 2021/12/16

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WAY-151932 Chemical Properties,Usage,Production

Uses

WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.

Biological Activity

WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively.

in vitro

WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV ₂ receptors in a dose-dependent manner with an EC ₅₀ of 0.74±0.07 nM.

in vivo

Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED ₅₀ =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.

target

IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)

References

[1] Molinari AJ, et al. Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800. DOI:10.1016/j.bmcl.2007.08.053
[2] Failli AA, et al. Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9. DOI:10.1016/j.bmcl.2005.10.107

WAY-151932 Preparation Products And Raw materials

Raw materials

Preparation Products

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WAY-151932 Suppliers

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WAY-151932

VNA-932

Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl-

WAY-VNA 932

WAY151932,WAY 151932

VNA-932 (WAY-151932)

220460-92-4