ChemicalBook > CAS DataBase List > CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)

Product Name
CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)
CAS No.
162760-96-5
Chemical Name
CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)
Synonyms
N-​ethyl]​piperazinyl]​methoxyphenyl)​WAY 100635;WAY100635;cyclohexanecarboxami​WAY100635 TRIHYDROCHLORIDE;WAY-100635;WAY 100635; WAY100635;Cyclohexanecarboxamide,N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-;N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxaMide
CBNumber
CB82448237
Molecular Formula
C25H34N4O2
Formula Weight
422.56
MOL File
162760-96-5.mol
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CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Property

Melting point:
>145oC (dec.)
Boiling point:
594.8±50.0 °C(Predicted)
Density 
1.154±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
pka
6.84±0.10(Predicted)
color 
Off-White to Pale Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
W498665
Product name
WAY100635
Packaging
250mg
Price
$215
Updated
2021/12/16
ApexBio Technology
Product number
A3933
Product name
WAY-100635
Packaging
10mg
Price
$102
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000230
Product name
WAY-100635 TRIHYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$792
Updated
2021/12/16
DC Chemicals
Product number
DC22622
Product name
WAY-100635
Purity
>98%
Packaging
1g
Price
$800
Updated
2021/12/16
Crysdot
Product number
CD31003127
Product name
WAY-100635
Purity
98+%
Packaging
10mg
Price
$64
Updated
2021/12/16
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CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Chemical Properties,Usage,Production

Uses

WAY 100635 exhibits high affinity and efficacy at the dopamine D4 receptor (1,2,3). WAY 100635 is a potent 5-HT1A antagonist.

Definition

ChEBI: N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide is a member of piperazines.

Biological Activity

5-ht1a receptors mediate various serotonergic functions and may be implicated in various pathologies including depressive and anxiety disorders, alzheimer’s disease, and schizophrenia. way-100635 is a potential spect ligands for the 5-ht1a receptor.

in vitro

way-100635 displaced specific binding of the 5-ht1a radioligand, [3h]8-oh-dpat, to rat hippocampal membranes with a plc50 of 8.87. in functional assays, way-100635 was a potent 5-ht1a receptor antagonist, with no evidence of any 5-htia receptor agonist or partial agonist activity. in the isolated guinea-pig ileum way-100635 was a potent and, at high concentrations, an insurmountable antagonist of the 5-ht1a receptor agonist action of 5-carboxamidotryptamine, with an apparent pa 2 value (at 0.3 nm) of 9.71 [2].

in vivo

way-100635 blocked the inhibitory action of 8-oh-dpat on dorsal raphe neuronal firing in the anaesthetised rat at doses which had no inhibitory action per se. in behavioural models, way-100635 itself induced no overt behavioural changes but potently antagonised the behavioural syndrome induced by 8-oh-dpat in the rat and guinea-pig (minimum effective dose = 0.003 mg/kg s.c. and id50 = 0.01 mg/kg s.c., respectively). way-100635 also blocked the hypothermia induced by 8-oh-dpat in the mouse and rat with id50 values of 0.01 mg/kg s.c. [2].

target

5-HT1A receptor

References

[1] al hussainy r, verbeek j, van der born d, braker ah, leysen je, knol rj, booij j, herscheid jk. design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of n-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-n-(pyridin-2-yl)cyclohexanecarboxamide (way-100635) as potential spect ligands for the 5-ht1a receptor. j med chem. 2011;54(10):3480-91.
[2] forster ea, cliffe ia, bill dj, dover gm, jones d, reilly y, fletcher a. a pharmacological profile of the selective silent 5-ht1a receptor antagonist, way-100635. eur j pharmacol. 1995;281(1):81-8.

CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Suppliers

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162760-96-5, CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)Related Search:


  • CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)
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  • C25H34N4O2