2-Bromo-4-butanolide
- Product Name
- 2-Bromo-4-butanolide
- CAS No.
- 5061-21-2
- Chemical Name
- 2-Bromo-4-butanolide
- Synonyms
- 3-Bromodihydrofuran-2(3H)-one;α-Bromo-γ-butyrolactone;3-Bromotetrahydrofuran-2-one;3-Bromdihydrofuran-2(3H)-on;AKOS 23;à-bromo-;NSC 11726;NSC 56959;α-Bromo-γ-butyroL;3-Bromo-2-furanone
- CBNumber
- CB0139728
- Molecular Formula
- C4H5BrO2
- Formula Weight
- 164.99
- MOL File
- 5061-21-2.mol
2-Bromo-4-butanolide Property
- Boiling point:
- 138 °C/6 mmHg (lit.)
- Density
- 1.786 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.508(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Acetone, Chloroform, Ethyl Acetate, Methanol
- form
- Clear Colourless to Light Yellow Liquid
- Specific Gravity
- 1.778 (20/4℃)
- Appearance
- Colorless to light yellow Liquid
- Sensitive
- Moisture Sensitive/Lachrymatory
- BRN
- 107800
- InChI
- InChI=1S/C4H5BrO2/c5-3-1-2-7-4(3)6/h3H,1-2H2
- InChIKey
- LFJJGHGXHXXDFT-UHFFFAOYSA-N
- SMILES
- O1CCC(Br)C1=O
- CAS DataBase Reference
- 5061-21-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 2(3H)-Furanone, 3-bromodihydro-(5061-21-2)
- EPA Substance Registry System
- 2(3H)-Furanone, 3-bromodihydro- (5061-21-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B59608
- Product name
- α-Bromo-γ-butyrolactone
- Purity
- 97%
- Packaging
- 25g
- Price
- $101
- Updated
- 2025/07/31
- Product number
- B59608
- Product name
- α-Bromo-γ-butyrolactone
- Purity
- 97%
- Packaging
- 100g
- Price
- $359
- Updated
- 2025/07/31
- Product number
- B1228
- Product name
- alpha-Bromo-gamma-butyrolactone
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- B1228
- Product name
- alpha-Bromo-gamma-butyrolactone
- Purity
- >95.0%(GC)
- Packaging
- 500g
- Price
- $493
- Updated
- 2025/07/31
- Product number
- B682070
- Product name
- α-Bromo-γ-butyrolactone
- Packaging
- 10g
- Price
- $45
- Updated
- 2021/12/16
2-Bromo-4-butanolide Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Liquid
Uses
Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1.
Synthesis
96-48-0
5061-21-2
General procedure for the synthesis of α-bromo-γ-butyrolactone from γ-butyrolactone (bromination step): in a 1000 mL reaction vessel equipped with a stirring device, refluxing device, thermometer, dropping funnel, and nitrogen introduction tube, 200 g (2.32 mol) of γ-butyrolactone and 2.76 g (0.086 mol based on 3.7 mol% of γ-butyrolactone) of sulfur were added as the catalyst. 431 g (2.70 mol) of bromine was loaded into a dropping funnel. Stirring was initiated, the reaction temperature was controlled not to exceed 40 °C, and the bromine was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was raised to about 90 °C and the reaction was maintained at this temperature for 1 hour. Subsequently, the temperature was raised to about 110°C and the reaction was continued for 3 hours.
References
[1] Patent: JP5837752, 2015, B2. Location in patent: Paragraph 0052; 0079-0081; 0082; 0085; 0086; 0088
[2] Journal of Porphyrins and Phthalocyanines, 2010, vol. 14, # 1, p. 89 - 100
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3074 - 3077
[4] Synlett, 2005, # 17, p. 2648 - 2652
[5] Organic Letters, 2011, vol. 13, # 14, p. 3670 - 3673
2-Bromo-4-butanolide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-4-butanolide manufacturers
- Product
- 2-Bromo-4-butanolide 5061-21-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1MT
- Release date
- 2025-09-12
- Product
- 2-Bromo-4-butanolide 5061-21-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2025-08-12
- Product
- 2-Bromo-4-butanolide 5061-21-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-09