ChemicalBook > CAS DataBase List > 2-Bromo-4-butanolide

2-Bromo-4-butanolide

Product Name
2-Bromo-4-butanolide
CAS No.
5061-21-2
Chemical Name
2-Bromo-4-butanolide
Synonyms
3-Bromodihydrofuran-2(3H)-one;α-Bromo-γ-butyrolactone;3-Bromotetrahydrofuran-2-one;3-Bromdihydrofuran-2(3H)-on;AKOS 23;à-bromo-;NSC 11726;NSC 56959;α-Bromo-γ-butyroL;3-Bromo-2-furanone
CBNumber
CB0139728
Molecular Formula
C4H5BrO2
Formula Weight
164.99
MOL File
5061-21-2.mol
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2-Bromo-4-butanolide Property

Boiling point:
138 °C/6 mmHg (lit.)
Density 
1.786 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.508(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Acetone, Chloroform, Ethyl Acetate, Methanol
form 
Clear Colourless to Light Yellow Liquid
Specific Gravity
1.778 (20/4℃)
Appearance
Colorless to light yellow Liquid
Sensitive 
Moisture Sensitive/Lachrymatory
BRN 
107800
InChI
InChI=1S/C4H5BrO2/c5-3-1-2-7-4(3)6/h3H,1-2H2
InChIKey
LFJJGHGXHXXDFT-UHFFFAOYSA-N
SMILES
O1CCC(Br)C1=O
CAS DataBase Reference
5061-21-2(CAS DataBase Reference)
NIST Chemistry Reference
2(3H)-Furanone, 3-bromodihydro-(5061-21-2)
EPA Substance Registry System
2(3H)-Furanone, 3-bromodihydro- (5061-21-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 2810
WGK Germany 
3
F 
21
Hazard Note 
Irritant/Keep Cold/Lachrymatory/Moisture Sensitive
TSCA 
Yes
HS Code 
29322980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B59608
Product name
α-Bromo-γ-butyrolactone
Purity
97%
Packaging
25g
Price
$101
Updated
2025/07/31
Sigma-Aldrich
Product number
B59608
Product name
α-Bromo-γ-butyrolactone
Purity
97%
Packaging
100g
Price
$359
Updated
2025/07/31
TCI Chemical
Product number
B1228
Product name
alpha-Bromo-gamma-butyrolactone
Purity
>95.0%(GC)
Packaging
25g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
B1228
Product name
alpha-Bromo-gamma-butyrolactone
Purity
>95.0%(GC)
Packaging
500g
Price
$493
Updated
2025/07/31
TRC
Product number
B682070
Product name
α-Bromo-γ-butyrolactone
Packaging
10g
Price
$45
Updated
2021/12/16
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2-Bromo-4-butanolide Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Liquid

Uses

Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1.

Synthesis

96-48-0

5061-21-2

General procedure for the synthesis of α-bromo-γ-butyrolactone from γ-butyrolactone (bromination step): in a 1000 mL reaction vessel equipped with a stirring device, refluxing device, thermometer, dropping funnel, and nitrogen introduction tube, 200 g (2.32 mol) of γ-butyrolactone and 2.76 g (0.086 mol based on 3.7 mol% of γ-butyrolactone) of sulfur were added as the catalyst. 431 g (2.70 mol) of bromine was loaded into a dropping funnel. Stirring was initiated, the reaction temperature was controlled not to exceed 40 °C, and the bromine was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was raised to about 90 °C and the reaction was maintained at this temperature for 1 hour. Subsequently, the temperature was raised to about 110°C and the reaction was continued for 3 hours.

References

[1] Patent: JP5837752, 2015, B2. Location in patent: Paragraph 0052; 0079-0081; 0082; 0085; 0086; 0088
[2] Journal of Porphyrins and Phthalocyanines, 2010, vol. 14, # 1, p. 89 - 100
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3074 - 3077
[4] Synlett, 2005, # 17, p. 2648 - 2652
[5] Organic Letters, 2011, vol. 13, # 14, p. 3670 - 3673

2-Bromo-4-butanolide Preparation Products And Raw materials

Raw materials

Bromine Gamma Butyrolactone

Preparation Products

SPIZOFURONE
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2-Bromo-4-butanolide Suppliers

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View Lastest Price from 2-Bromo-4-butanolide manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Bromo-4-butanolide 5061-21-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1MT
Release date
2025-09-12
Shaanxi Dideu New Materials Co. Ltd
Product
2-Bromo-4-butanolide 5061-21-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-09
RongNa Biotechnology Co.,Ltd
Product
2-Bromo-4-butanolide 5061-21-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000kg
Release date
2024-03-26

5061-21-2, 2-Bromo-4-butanolideRelated Search:

BETA-BUTYROLACTONE TRIOXSALEN Citric acid Tungsten p-Toluenesulfonic acid Dimethyl sulfoxide Sodium carbonate Zinc oxide Manganese dioxide Diethylstilbestrol Bromine Gamma Butyrolactone ALPHA-BROMO-ALPHA-METHYL-GAMMA-BUTYROLACTONE ALPHA-BROMO-GAMMA-VALEROLACTONE 2-Bromo-4-butanolide SALOR-INT L132004-1EA A-BROMO-A-TRIFLUOROACETYL-G-BUTYROLACTONE, HYDRATE

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