ChemicalBook > CAS DataBase List > 5-ISOTHIAZOLECARBOXYLIC ACID

5-ISOTHIAZOLECARBOXYLIC ACID

Product Name: 5-ISOTHIAZOLECARBOXYLIC ACID
CAS No.: 10271-85-9
Chemical Name: 5-ISOTHIAZOLECARBOXYLIC ACID
Synonyms: 5-ISOTHIAZOLECARBOXYLIC ACID;ISOTHIAZOLE-5-CARBOXYLIC ACID;1,2-thiazole-5-carboxylic acid;8-Isoquinoline-methaneaminedihydrochloride
CBNumber: CB2317896
Molecular Formula: C4H3NO2S
Formula Weight: 129.14
MOL File: 10271-85-9.mol

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5-ISOTHIAZOLECARBOXYLIC ACID Property

Melting point:: 196-200℃ (decomposition)
Boiling point:: 178.4±23.0℃ (760 Torr)
Density: 1.525±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 61.7±22.6℃
storage temp.: 2-8°C
form: Solid
pka: 1.23±0.10(Predicted)
color: Off-white to light brown

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Safety

HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: I917608
Product name: Isothiazole-5-carboxylicacid
Packaging: 50mg
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 280318
Product name: Isothiazole-5-carboxylic acid
Packaging: 100mg
Price: $460
Updated: 2021/12/16

Apolloscientific

Product number: OR313078
Product name: Isothiazole-5-carboxylic acid
Packaging: 1g
Price: $513
Updated: 2021/12/16

Apolloscientific

Product number: OR313078
Product name: Isothiazole-5-carboxylic acid
Packaging: 250mg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0030214
Product name: ISOTHIAZOLE-5-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1149.23
Updated: 2021/12/16

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5-ISOTHIAZOLECARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

Isothiazole-5-carboxylic acid (8-Isoquinoline-methaneaminedihydrochloride) is an organic compound with antibacterial, anticancer and anti-inflammatory properties. Isothiazole-5-carboxylic acid can be used to develop novel compounds to combat various diseases. Isothiazole-5-carboxylic acid exhibits a wide range of potential pharmacological activities and helps improve existing inhibitory schemes.

Synthesis

15901-66-3

10271-85-9

Methyl isothiazole-5-carboxylate (0.50 g, 3.49 mmol) was dissolved in a THF/MeOH solvent mixture (20 mL/5 mL) at room temperature, followed by slow addition of 1N NaOH solution (5.24 mL, 5.24 mmol). The reaction mixture was stirred continuously for 16 h at room temperature and the completion of the reaction was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the reaction mixture was acidified to pH 2 with 1N HCl solution, at which point a precipitate was observed to be generated. The precipitate was separated by filtration and dried to afford the target product isothiazole-5-carboxylic acid (Compound 2) as a beige solid in a yield of 0.35 g (76% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6) with chemical shifts of δ 8.69 (d, 1H) and 7.85 (d, 1H), respectively.

References

[1] Patent: US2007/105864, 2007, A1. Location in patent: Page/Page column 151-152
[2] Patent: US2007/117804, 2007, A1. Location in patent: Page/Page column 78

5-ISOTHIAZOLECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-ISOTHIAZOLECARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 5-ISOTHIAZOLECARBOXYLIC ACID 10271-85-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-03

10271-85-9, 5-ISOTHIAZOLECARBOXYLIC ACIDRelated Search:

thiazol-3-one Isothiazolo[5,4-b]pyridin-3-amine isothiazole-3-carbonitrile Isothazole-4-boronic acid ISOTHIAZOLE-5-CARBOXYLIC ACID METHYL ESTER 4-Carboxyisothiazole Isothiazol-4-ylMethanaMine 3-Isothiazolecarboxamide isothiazol-3-ylMethanol ISOTHIAZOLE-5-CARBALDEHYDE Isothiazole-5-methanol isothiazole-3-carbaldehyde 5-Isothiazolecarboxamide 3-Isothiazolemethanamine isothiazol-3-aMine 3-Isothiazolecarboxylic acid 4-ISOTHIAZOLECARBOXAMIDE 4-Isothiazolecarboxylic acid, Methyl ester

5-ISOTHIAZOLECARBOXYLIC ACID

8-Isoquinoline-methaneaminedihydrochloride

1,2-thiazole-5-carboxylic acid

ISOTHIAZOLE-5-CARBOXYLIC ACID

10271-85-9