3-Isothiazolecarboxylic acid
- Product Name
- 3-Isothiazolecarboxylic acid
- CAS No.
- 4576-90-3
- Chemical Name
- 3-Isothiazolecarboxylic acid
- Synonyms
- 3-Carboxyisothiazole;3-Isothiazolecarboxylic 3-ISOTHIAZOLE CARBOXYLIC ACID;isothiazole-3-carboxylic acid;1,2-thiazole-3-carboxylic acid;Isothiazole-3-carboxylicacid97%;Isothiazole-3-carboxylic acid 97%;3-Carboxyisothiazole, 1,2-Thiazole-3-carboxylic acid
- CBNumber
- CB7966464
- Molecular Formula
- C4H3NO2S
- Formula Weight
- 129.14
- MOL File
- 4576-90-3.mol
3-Isothiazolecarboxylic acid Property
- Boiling point:
- 178 °C
- Density
- 1.525
- Flash point:
- 62 °C
- storage temp.
- 2-8°C
- pka
- 1.08±0.10(Predicted)
- form
- solid
- color
- Beige
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- I917613
- Product name
- 3-Isothiazolecarboxylicacid
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- I917613
- Product name
- 3-Isothiazolecarboxylicacid
- Packaging
- 100mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- I13225
- Product name
- Isothiazole-3-carboxylicacid
- Purity
- 95%
- Packaging
- 500mg
- Price
- $361
- Updated
- 2021/12/16
- Product number
- 070633
- Product name
- Isothiazole-3-carboxylic acid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $405
- Updated
- 2021/12/16
- Product number
- 8H21-1-Z1
- Product name
- Isothiazole-3-carboxylic acid
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $199
- Updated
- 2021/12/16
3-Isothiazolecarboxylic acid Chemical Properties,Usage,Production
Uses
3-Isothiazolecarboxylic acid
Synthesis
693-92-5
4576-90-3
The general procedure for the synthesis of isothiazole-3-carboxylic acid using 3-methylisothiazole as starting material was as follows: chromium(IV) oxide (9.00 mmol) was added batchwise to a solution of 3-methylisothiazole (3.03 mmol) dissolved in fuming sulphuric acid (10 mL) under the condition of ice bath at 0°C. The reaction mixture was gradually warmed to room temperature and the reaction was stirred at this temperature for 16 hours. Upon completion of the reaction, the mixture was diluted with ice water (100 mL) followed by multiple extractions with ether (6 x 200 mL). All organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by preparative high performance liquid chromatography (HPLC) to give isothiazole-3-carboxylic acid in 13% yield as a white solid. The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6) and LC/MS: 1H-NMR δ 3.43 (s, 1H), 9.17 (d, 1H), 7.80 (d, 1H), 3.43 (s, 1H); LC/MS (ESI) m/z [M + 1]+ 128.
References
[1] Patent: WO2018/160878, 2018, A1. Location in patent: Page/Page column 183
[2] Patent: WO2009/55437, 2009, A2. Location in patent: Page/Page column 66
[3] Journal of the Chemical Society, 1965, p. 7274 - 7276
[4] Journal of the Chemical Society, 1965, p. 7277 - 7282
3-Isothiazolecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Isothiazolecarboxylic acid manufacturers
- Product
- 3-Isothiazolecarboxylic acid 4576-90-3
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10