Vardenafil

ChemicalBook > CAS DataBase List > Vardenafil

Product Name: Vardenafil
CAS No.: 224785-90-4
Chemical Name: Vardenafil
Synonyms: Levitra;VARDENAFIL HCL TRIHYDRATE;FADINAF;Vardenafil powder;Vardenafil (Leviitra);Vivanza;BAY38-9456;Sildelafil;VARDENAFIL;Fardenafil
CBNumber: CB2321327
Molecular Formula: C23H32N6O4S
Formula Weight: 488.6
MOL File: 224785-90-4.mol

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Vardenafil Property

Melting point:: 230-235°C
Density: 1.37
vapor pressure: 0.001Pa at 71.34℃
Flash point:: 9℃
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: >22.5mg/mL in DMSO
form: Powder
pka: 9.86±0.20(Predicted)
Water Solubility: 7mg/L at 20℃
BCS Class: 2
InChI: InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)
InChIKey: NOIHTGOGFDFCBN-UHFFFAOYSA-N
SMILES: N12C(CCC)=NC(C)=C1C(=O)N=C(C1=CC(S(N3CCN(CC)CC3)(=O)=O)=CC=C1OCC)N2
LogP: 2.5 at 23℃

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Safety

Hazard Codes: F,Xn
Risk Statements: 11-20/21/22-36
Safety Statements: 16-36/37
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1
Hazardous Substances Data: 224785-90-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V-902
Product name: Vardenafil dihydrochloride solution
Purity: 1.0?mg/mLinmethanol(asfreebase),ampuleof1?mL,certifiedreferencemateri
Packaging: 1mL
Price: $171
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0008769
Product name: VARDENAFIL
Purity: 95.00%
Packaging: 10MG
Price: $255.15
Updated: 2021/12/16

AK Scientific

Product number: E429
Product name: Vardenafil
Packaging: 10mg
Price: $98
Updated: 2021/12/16

Matrix Scientific

Product number: 168056
Product name: Vardenafil
Packaging: 1g
Price: $472
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: D34389
Product name: Vardenafil-d5HCl
Packaging: 1mg
Price: $675
Updated: 2021/12/16

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Vardenafil Chemical Properties,Usage,Production

Description

Vardenafil is a new PDE5 inhibitor launched for oral treatment of male erectile dysfunction and it has significant structural similarity with sildenafil (Viagra^?), which was the first PDE5 inhibitor introduced in 1998 for this indication. Vardenafil is synthesized in three steps starting with a cyclization reaction of 2-ethyoxybenzamidine with 2-butyramidopropionic acid and ethoxyallyl chloride to construct the imidazotriazine ring system, followed by sulfonation to the corresponding sulfonyl chloride and subsequent condensation with 1-ethylpiperazine. The potency of PDE5 inhibition by vardenafil (IC₅₀=0.7 nM) is ～10 times greater than that of sildenafil (IC₅₀=6.6 nM). Vardenafil is typically administered in single doses of 10 and 20 mg. The time to reach maximum plasma concentration is 0.75 h, which is slightly shorter than those of sildenafil (t_max=1.16 h) and tadalafil (t_max=2h), and the half-life is 4–5 h. Although it is almost completely absorbed following oral administration, the mean absolute bioavailability of a 10 mg dose is ～15%, resulting from extensive first pass metabolism. Vardenafil is metabolized in the liver primarily by CYP3A4 and is eliminated mainly in feces. In clinical studies, 10–20 mg doses of vardenafil was well tolerated and efficacious in patients with ED of various severities, including subjects with comorbidities such as diabetes mellitus or hypertension or hyperlipidemia. The side-effect profile of vardenafil is similar to that of sildenafil, with headache, flushing, dyspepsia and nasal congestion being the most common adverse events. Vardenafil has systemic vasodilatory properties, which can cause transient decrease in supine blood pressure; however, it does not appear to translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 20 and 40 mg vardenafil were 6.9 and 4.3 mmHg, respectively, when compared to placebo. However, single and multiple oral doses of vardenafil up to 40 mg produced no clinically relevant changes in the ECGs of normal male volunteers.

Originator

Bayer AG (Germany)

Uses

erectil dysfunction;PDE5 inhibitor

Uses

Vardenafil Hydrochloride Trihydrate (cas# 330808-88-3) has therapeutic applications and used in cosmetics and personal care products.

Definition

ChEBI: The sulfonamide resulting from formal condensation of the sulfo group of 4-ethoxy-3-(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one-2-yl)benzenesulfonic acid and the secondary amino group of 4-ethylpiperazine.

brand name

Levitra

Flammability and Explosibility

Non flammable

Clinical Use

Treatment of erectile dysfunction

Drug interactions

Potentially hazardous interactions with other drugs
Alpha-blockers: enhanced hypotensive effect - avoid for 6 hours after alpha-blockers (max dose 5 mg).
Antifungals: concentration increased by ketoconazole, and itraconazole - avoid concomitant use.
Antivirals: concentration increased by fosamprenavir, indinavir and ritonavir- avoid with indinavir and ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid; avoid with telaprevir, use tipranavir with caution.
Cobicistat: concentration of vardenafil possibly increased - reduce dose of vardenafil.
Grapefruit juice: concentration possibly increased - avoid concomitant use.
Nicorandil: possibly enhanced hypotensive effect - avoid concomitant use.
Nitrates: possibly enhanced hypotensive effect - avoid concomitant use.
Riociguat: enhanced hypotensive effect - avoid concomitant use.

Metabolism

Vardenafil is metabolised in the liver primarily by cytochrome P450 isoenzymes CYP3A4 (the major route) as well as CYP3A5 and CYP2C isoforms. The major metabolite produced by desethylation of vardenafil also has some activity.
Vardenafil is excreted as metabolites mainly in the faeces (91 to 95
%), and to a lesser extent in the urine.

Vardenafil Preparation Products And Raw materials

Raw materials

Preparation Products

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Vardenafil Suppliers

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View Lastest Price from Vardenafil manufacturers

Wuhan Cell Pharmaceutical Co., Ltd

Product: Vardenafil 224785-90-4
Price: US $2.00-1120.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-04-14

Dorne Chemical Technology co. LTD

Product: Vardenafil 224785-90-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Shanghai Aosiris new Material Technology Co., LTD

Product: Vardenafil 224785-90-4
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10 tons
Release date: 2024-04-19

224785-90-4, VardenafilRelated Search:

Methyl acetate DIETHOXYMETHANE Tadalafil vardenafil Triethylamine hydrochloride Vardenafil Hydrochloride Trihydrate 224785-90-4 / Bensulfuron methyl Topotecan hydrochloride Methyl acrylate Kresoxim-methyl Ethyl vinyl ether Ethoxyethyne Citrazinic acid Thiophanate-methyl Ethoxyquin Trimethylamine hydrochloride Ninhydrin hydrate METSULFURON METHYL Levitra Vardenafil

VARDENAFIL(SUBJECTTOPATENTFREE)

VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)

2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one

Vardenafil hydrochloride trihydrate 99%

Vardenafil Hydrochloride Trihydrate Cas# 224785-90-4 For Sale

Manufacturers Supply best quality Vardenafil hydrochloride trihydrate 224785-90-4 CAS NO.224785-90-4

FADINAF

1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine hydrochloride trihydrate

Levitra

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one

Methanol (test Vardenafil diHCl, 1.0 mg/mL as free base）

Vardenafil (Vivanza)

Vivanza

BAY38-9456

2-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[1,5-f][1,2,4]triazin-4(3H)-one hydrochloride trihydrate

Zopiclone-D4 solution

2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride Trihydrate

VARDENAFIL HCL TRIHYDRATE

VARDENAFIL HYDROCHLORIDE, 98.5-101%

Vardenafil (Vardenafil hydrochloride salt)

Vardenafil Hydrochloride Trihydrate (BAY38-9456)

2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-propyl-1H,4H-imidazo[4,3-f][1,2,4]triazin-4-one hydrochloride

Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-

Sildelafil

Vardenafil white powder

Vardenafil hydrochloride trihydrate USP/EP/BP

VARDENAFIL

Vardenafil powder

levitra vardenafil

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

VardenafilQ: What is Vardenafil Q: What is the CAS Number of Vardenafil Q: What is the storage condition of Vardenafil Q: What are the applications of Vardenafil

Vardenafil (Leviitra)

Fardenafil

ardenafil hcl trihydrate

Valrdenafi

Vardenafil hydrochloride trihydrate/Levitra

Vardenafil Monomer

Vardenafil (free alkali)

Vardenafil in methanol

Wardenafil

Vardenafil CAS

224785-90-4

C23H39ClN6O7S

C23H32N6O4SHCl3H2O

C23H32N6O4S

API

Levitra

Inhibitor

Erectile Dysfunction