GS 39783
- Product Name
- GS 39783
- CAS No.
- 39069-52-8
- Chemical Name
- GS 39783
- Synonyms
- GS 39783;GS 39783, GABAB positive allosteric modulator;N,N'-DICYCLOPENTYL-2-(METHYLTHIO)-5-NITRO-4,6-PYRIMIDINEDIAMINE;N4,N6-Dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine;N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediaamine;4,6-Pyrimidinediamine, N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-;N,N'-DICYCLOPENTYL-2-METHYLSULFANYL-5-NITRO-PYRIMIDINE-4,6-DIAMINE
- CBNumber
- CB2323806
- Molecular Formula
- C15H23N5O2S
- Formula Weight
- 337.44
- MOL File
- 39069-52-8.mol
GS 39783 Property
- storage temp.
- Store at RT
- solubility
- DMSO: ~8 mg/mL
- form
- powder
- color
- yellow
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1520
- Product name
- GS39783
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $95.7
- Updated
- 2022/05/15
- Product number
- SML1520
- Product name
- GS39783
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $386
- Updated
- 2022/05/15
- Product number
- 29482
- Product name
- GS-39783
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 29482
- Product name
- GS-39783
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 29482
- Product name
- GS-39783
- Packaging
- 25mg
- Price
- $286
- Updated
- 2024/03/01
GS 39783 Chemical Properties,Usage,Production
Uses
GS 39783 is an allosteric positive modulator of GABAB receptors. GS 39783 attenuates acute cocaine-induced hyperlocomotion and blocks cocaine-induced Fos induction in the striatal complex.
Definition
ChEBI: N4,N6-dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine is an aryl sulfide.
Biological Activity
Novel positive allosteric modulator of GABA B receptor function. Potentiates the effects of GABA on [ 35 S]GTP γ S binding at recombinant and native GABA B receptors (EC 50 values are 2.1 and 3.1 μ M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.
storage
Store at RT
GS 39783 Preparation Products And Raw materials
Raw materials
Preparation Products
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