ChemicalBook > CAS DataBase List > WUWEIZISU C

WUWEIZISU C

Product Name: WUWEIZISU C
CAS No.: 61301-33-5
Chemical Name: WUWEIZISU C
Synonyms: WUWEIZISU C;,8-dimethyl-;SCHIZANDRIN C;Schizandrin C-RM;(S)-(-)-Schisandrin C;WUWEIZISU C USP/EP/BP;Schisandrin C >=98% (HPLC);Schisandrin C (Schizandrin-C;Schisandrin C, 10 mM in DMSO;Schisandrin C (S)-(-)-Schisandrin C
CBNumber: CB2327435
Molecular Formula: C22H24O6
Formula Weight: 384.42
MOL File: 61301-33-5.mol

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WUWEIZISU C Property

Melting point:: 122-123℃
Boiling point:: 549.2±50.0 °C(Predicted)
Density: 1.232
storage temp.: 2-8°C
solubility: DMSO : 8.33 mg/mL (21.67 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: powder
color: White
LogP: 5.623 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00323
Product name: Schisandrin C
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $585
Updated: 2025/07/31

Cayman Chemical

Product number: 27475
Product name: Schisandrin C
Packaging: 1mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 27475
Product name: Schisandrin C
Packaging: 25mg
Price: $1075
Updated: 2024/03/01

Cayman Chemical

Product number: 27475
Product name: Schisandrin C
Packaging: 5mg
Price: $306
Updated: 2024/03/01

Cayman Chemical

Product number: 27475
Product name: Schisandrin C
Packaging: 10mg
Price: $502
Updated: 2024/03/01

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WUWEIZISU C Chemical Properties,Usage,Production

Description

Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities. It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G₁ phase when used at a concentration of 100 μM. Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells. It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E₂ (PGE₂; ), TNF-α, IL-1β, and IL-6 in mouse primary microglia. In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.

Chemical Properties

Colorless crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Schisandra chinensis.

Uses

Schisandrin C potently inhibits proprotein convertase subtillsin-kexin type 9 (PCSK9) mRNA expression. Also, it displays strong protective effects in SH-SY5Y cells against serum and glucose deprivation (SGD) injury.

in vivo

Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously^[3].

Animal Model:	Aβ1-42-induced Alzheimer’s disease mice^[3]
Dosage:	15-150 μg/kg
Administration:	Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days
Result:	Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice.

References

[1] LI X Y. Bioactivity of neolignans from fructus Schizandrae.[J]. Memorias do Instituto Oswaldo Cruz, 1991, 86 Suppl 2: 31-37. DOI: 10.1590/s0074-02761991000600010
[2] CHEOL PARK. Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells.[J]. International journal of molecular medicine, 2009, 24 4: 495-502. DOI: 10.3892/ijmm_00000258
[3] JEONG-SEOK KIM Ho K Y. Schisandrin C enhances mitochondrial biogenesis and autophagy in C2C12 skeletal muscle cells: potential involvement of anti-oxidative mechanisms.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2018, 391 2: 197-206. DOI: 10.1007/s00210-017-1449-1
[4] SUN YOUNG PARK . Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia[J]. International immunopharmacology, 2013, 17 2: Pages 415-426. DOI: 10.1016/j.intimp.2013.06.032
[5] YIMING JIANG . Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation[J]. Chemico-Biological Interactions, 2015, 231: Pages 83-89. DOI: 10.1016/j.cbi.2015.02.022

WUWEIZISU C Preparation Products And Raw materials

Raw materials

Preparation Products

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WUWEIZISU C Suppliers

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View Lastest Price from WUWEIZISU C manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Schisandrin C 61301-33-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-27

Career Henan Chemical Co

Product: WUWEIZISU C 61301-33-5
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

61301-33-5, WUWEIZISU CRelated Search:

WUWEIZISU B,WUWEIZISU B 98.0% BY HPLC Schisandrin schisanhenol WUWEIZISU A Schisantherin A (5S)-6α,7β-Dimethyl-1,2,3,11,12-pentamethoxy(5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene)-5α,6β,10-triol 5-benzoate Gomisin A 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)- Arisantetralone C 3,5,6,6-tetraMethyl-4,5,5a,6,7,8-hexahydrocyclopenta[c]pentalen-2(1H)-one schisantherin D SchisandraeChinensis polysaccharides Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer 4,4'-Biphenol 4-HYDROXY-4'-METHOXYBIPHENYL 4,4'-Dimethoxybiphenyl Masoprocol 2,2'-DIMETHOXYBIPHENYL

SCHIZANDRIN C

WUWEIZISU C

,8-dimethyl-

cycloocta(1,2-f:3,4-f’)bis(1,3)benzodioxole6,7,8,9-tetrahydro-1,13-dimethoxy-7

(6R,7S,13aS)-5,6,7,8-Tetrahydro-13,14-dimethoxy-6,7-dimethylcycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole

(S)-(-)-Schisandrin C

Schisandrin C (Schizandrin-C

Schisandrin C (S)-(-)-Schisandrin C

Cycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, (6R,7S,13aS)-

Schisandrin C >=98% (HPLC)

WUWEIZISU C USP/EP/BP

13,14-dimethoxy-6,7-dimethyl-5,6,7,8-tetrahydro[1,3]benzodio...

(6R,7S)-13,14-Dimethoxy-6,7-dimethyl-5,6,7,8-tetrahydro[1,3]benzodioxolo[5',6':3,4]cycloocta[1,2-f][1,3]benzodioxole

Schizandrin C-RM

Schisandrin C, 10 mM in DMSO

61301-33-5

C22H24O6

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

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