Santonin
- Product Name
- Santonin
- CAS No.
- 481-06-1
- Chemical Name
- Santonin
- Synonyms
- Semenen;SANTONIN;NSC 4900;A-SANTONIN;l-Santonin;α-santonin;Santonin>SANTONIN, A-;SANTONIN 97%;Santonin CRS
- CBNumber
- CB2331234
- Molecular Formula
- C15H18O3
- Formula Weight
- 246.3
- MOL File
- 481-06-1.mol
Santonin Property
- Melting point:
- 172-173 °C(lit.)
- Boiling point:
- 329.3°C (rough estimate)
- Density
- 1.5900
- refractive index
- -172.5 ° (C=2, CHCl3)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly)
- color
- White to Off-White
- Water Solubility
- 0.2g/L(17.5 ºC)
- Merck
- 14,8361
- BRN
- 89489
- Stability:
- Hygroscopic
- LogP
- 1.600 (est)
- CAS DataBase Reference
- 481-06-1(CAS DataBase Reference)
- EPA Substance Registry System
- Santonin (481-06-1)
Safety
- Hazard Codes
- Xn,Xi,T+
- Risk Statements
- 22-36/37/38-26/27/28
- Safety Statements
- 22-24/25-45-37-36-28-26
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- LE3150000
- HS Code
- 2932.99.7000
- HazardClass
- 6.1(a)
- PackingGroup
- II
N-Bromosuccinimide Price
- Product number
- PHL80931
- Product name
- α-Santonin
- Purity
- phyproof?ReferenceSubstance
- Packaging
- 100mg
- Price
- $262
- Updated
- 2024/03/01
- Product number
- S1250
- Product name
- (?)-α-Santonin
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $51.7
- Updated
- 2022/05/15
- Product number
- 53653
- Product name
- (?)-α-Santonin
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $118
- Updated
- 2022/05/15
- Product number
- S0521
- Product name
- Santonin
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $80
- Updated
- 2024/03/01
- Product number
- S0521
- Product name
- Santonin
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $316
- Updated
- 2024/03/01
Santonin Chemical Properties,Usage,Production
Description
Santonin is a lactone compound extracted from the flower bud of Artemisia cina
Berg in Compositae, crown daisy chrysanthemum or other plants in Artemisia. It
has been recorded in ancient China . Its English name is santonica wormseed,
Chinese alias is ‘quhaosu’ and Latin name is Seriphidium cinum (Berg ex Poljak.)
Pol-jak. . Santonica wormseed, a variant name for Artemisia
cina Berg, is the leaf and anthotaxy of Artemisia cina Berg in sagebrush plants in
Compositae. There are more than 100 plus in sagebrush, in which about 30 plus live
in China, and parts of them can be used medicinally.
Santonica wormseed, used as raw material to extract and manufacture santonin,
lives in cold, dry sandy loam. The place of origin is the Southern Central Asia in
the former Soviet Union. China introduced the earliest cultivation in Xinjiang, and
now it is introduced and cultivated in the North, Northeast and Northwest China.
Santonica wormseed mainly contains hispidulin, quercetin and caffeic acid, and its flower contains 1–3.5% α-santonin, 1–3% artemisinin and volatile oil (mainly
is 1, 8-cineole) and so on. Leaf also contains a small amount of α-santonin. In
addition, it also contains β-cintonin, 3,4,5,7-tetrahydroxy-3-methoxyflavone7-
glucoside and aglucone.
Physical properties
Appearance: a colourless prism crystal or white crystalline powder, odourless, a
little taste bitter and turning yellow in the sunlight. Solubility: hardly soluble in
water, sparingly soluble in ethanol, freely soluble in boiling ethanol and chloroform
and slightly soluble in diethyl ether. Melting point: 170–174 °C. Specific optical
rotation: ?170 to ?175°, determined on 1% ethanol solution at 25 °C.
Santonin is a kind of ketolide with two double bonds. It forms a salt by the ring opening when dissolving in alkaline solutions and reforms ketolide by
acidification.
History
The study on the chemical properties and structure of santonin was carried out at the end of the nineteenth century all the earliest research works were from the Italian scholars, such as Cannizzaro, Andreocci, Gucci, Francesconi, etc. The chemical structures determined before 1910 were all not exactly correct. Until 1929–1930, British scholars, Clemo, Haworth and Walton, finally determined the exact structure of santonin for the transformation from synthesized santonin into desmotroposanto nin and santonous acid. However, until 1940, there were no reports on structural configuration. Chinese scholars, Huang Minglong et al., basically completed the research work on the structural configuration of santonin in 1951, and the results were proved by Japanese scholars, Abe, Y. and Harukawa et al. in 1954.
Uses
anthelmintic
Uses
(-)-Santonin is a sesquiterpene lactone derivative which acts as an anti-pyretic agent when tested with subjects antagonized by haloperidol. Causes a decrease in temperature of mammals.
Uses
(?)-α-Santonin has been used as a eudesmane-type sesquiterpene to study its effects on impairment of 231MFP breast cancer cell survival.
Definition
ChEBI: A santonin that is 3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione substituted by methyl groups at positions 3, 5a and 9.
Indications
As a kind of deworming drug, santonin was effective for the treatment of human roundworm infection, but it is no longer in use at present because of the development of more effective medicines.
World Health Organization (WHO)
Santonin, a crystalline lactone obtained from flowerheads of species of Artemisia, was formerly used as an anthelminthic. Its use was associated with a range of adverse effects, mainly involving the sense organs and the central nervous system, some of which were fatal. It has been superseded by other less toxic and more effective anthelminthics.
General Description
(?)-α-Santonin is a sesquiterpene lactone. It is found in the genus Artemisia.
Biochem/physiol Actions
(?)-α-Santonin exhibits anti-helminthic properteis. It exhibits therapeutic effects against intestinal round worms.
Pharmacology
Santonin has a roundworm-expelling effect. It can excite worm’s ganglion which leads the worm not to be adsorbed in the intestinal wall, and then the worm is excreted out of the body after using laxatives. The effect is limited to the round worm, and it has little effect on other helminth. Excessive application can cause toxic effect. When it is excreted in urine, it can make the urine dark yellow or pink. It can be used in the treatment of ascariasis. During the medication, grease should be avoided, and laxative needs to be used such as salts. Patients with hepatosis, nephrosis and acute gastritis must contraindicate its use. The lethal dose 50 (LD50) injected under the skin of mice is 250–400 mg/kg.
Clinical Use
Santonin has been used for a long time as a kind of deworming drug. Its mechanism
is between inhibitory effect on γ-GABA and excitatory effect of cholinergic func tion. It also acts on the human central nervous system and can cause some adverse
effects, such as dizziness, leipopsychia, headache, epilepsy, xanthopsia, paresthesia
and so on
Santonin is easily dissolved and absorbed in the intestine due to alkaline intesti nal fluid and solvent effect of bile salts. Especially, it can cause severe toxic reaction
more easily for increasing absorption because intake of fatty food promotes bile
production, secretion and release.
Santonin has obvious central nervous system toxicity. A small amount can cause
colour deficiency, and a large amount can cause epileptiform, excessive excitement
turning into severe repression and even coma. Santonin is a highly toxic substance.
Children’s lethal dose is 0.15 g; adults’ lethal dose is about 1 g. Santonin has already
been phased out for the toxicity.
Santonin Preparation Products And Raw materials
Raw materials
Preparation Products
Santonin Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40240
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44700
- Advantage
- 61
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9664
- Advantage
- 60
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4941
- Advantage
- 60
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22519
- Advantage
- 55
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25014
- Advantage
- 65
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3989
- Advantage
- 66
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8073
- Advantage
- 58
- Tel
- 27-81302488 18007166089
- Fax
- 027-81302088
- info@dkybpc.com
- Country
- China
- ProdList
- 2024
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15185
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15885
- Advantage
- 55
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8147
- Advantage
- 55
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 7059
- Advantage
- 55
- Tel
- 0571-87157530-8002 15267169049
- Fax
- 0571-87156470
- sales@dingyanchem.com
- Country
- China
- ProdList
- 1997
- Advantage
- 58
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10457
- Advantage
- 58
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20810
- Advantage
- 60
- Tel
- 021-61847300 13341622919
- Fax
- 021-61847300
- shcss01@163.com
- Country
- China
- ProdList
- 4809
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 028-85370565-229 18080489829
- 3004654993@qq.com
- Country
- China
- ProdList
- 9218
- Advantage
- 60
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 10007
- Advantage
- 58
- Tel
- 021-021-52271985 17721149837
- Fax
- +86 (21) 52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 19806
- Advantage
- 60
- Tel
- 021-021-57127007-6622-6622 15618937986
- Fax
- +86 (21) 5132-0077
- zhaok@nature-standard.com
- Country
- China
- ProdList
- 3928
- Advantage
- 58
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15952
- Advantage
- 58
- Tel
- 029-86629612 18202932191
- sales@pioneerbiotech.com
- Country
- China
- ProdList
- 337
- Advantage
- 55
- Tel
- 400-6387771-6039 18920564737
- sales@heowns.com
- Country
- China
- ProdList
- 20641
- Advantage
- 60
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20569
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 010-010-62971590 18548936886
- Fax
- 010-62340519
- 3462612863@qq.com
- Country
- China
- ProdList
- 6912
- Advantage
- 58
- Tel
- 025-025-51191215 18013836722
- Fax
- 025-51191215
- 2399235533@qq.com
- Country
- China
- ProdList
- 4933
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 56057
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4698
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23556
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10522
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 26925
- Advantage
- 58
- Tel
- +86-27-8439 4403 18971486879
- Fax
- +86-27-8439 4403
- sales@chemnorm.com
- Country
- CHINA
- ProdList
- 2935
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28180
- Advantage
- 58
- Tel
- 18616526224
- lianshuo@vip.126.com
- Country
- China
- ProdList
- 9610
- Advantage
- 58
- Tel
- 21-询价2461152566优先处理 13162884212
- 2461152566@qq.com
- Country
- China
- ProdList
- 1112
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39916
- Advantage
- 58
- Tel
- 028-028-85142057 19983342022
- Fax
- 028-85142057
- 3005359975@qq.com
- Country
- China
- ProdList
- 1996
- Advantage
- 58
- Tel
- 021-54721350 13524668266
- Fax
- 021-5
- 2881505714@qq.com
- Country
- China
- ProdList
- 7878
- Advantage
- 58
- Tel
- +86-29-87569266 15319487004
- Fax
- 029-88380327
- 1015@dideu.com
- Country
- China
- ProdList
- 2263
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
View Lastest Price from Santonin manufacturers
- Product
- Santonin 481-06-1 481-06-1
- Price
- US $15.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-15
- Product
- SANTONIN 481-06-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-18
- Product
- Santonin 481-06-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 tons
- Release date
- 2020-04-27