Apalutamide Acid Impurity

Product Name: Apalutamide Acid Impurity
CAS No.: 1332391-04-4
Chemical Name: Apalutamide Acid Impurity
Synonyms: AP-COOH;APLA-COOH;APT-api-imF;Apalutamide-COOH;Apatamide impurity 2;Apalutamide impurity 01;Apalutamide Acid Impurity;Apalutamide Impurity 1 Sodium Salt;4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorobenzoic acid;Benzoic acid, 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-
CBNumber: CB23312856
Molecular Formula: C20H12F4N4O3S
Formula Weight: 464.39
MOL File: 1332391-04-4.mol

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Apalutamide Acid Impurity Property

Boiling point:: 661.7±65.0 °C(Predicted)
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 2.81±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Apalutamide Acid Impurity Chemical Properties,Usage,Production

Uses

Apalutamide-COOH is a metabolite of Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].

References

[1] Nicholas D. Smith, et al. Androgen receptor modulators and uses thereof. WO2011103202A2.

Apalutamide Acid Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

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1332391-04-4, Apalutamide Acid ImpurityRelated Search:

Apalutamide Acid Impurity

Apalutamide-COOH

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorQ: What is 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluor Q: What is the CAS Number of 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluor

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorobenzoic acid

Apalutamide Impurity 1 Sodium Salt

AP-COOH

Benzoic acid, 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-

Apatamide impurity 2

Apalutamide impurity 01

APLA-COOH

APT-api-imF

1332391-04-4

133239-92-0