ChemicalBook > CAS DataBase List > 7-(2-HYDROXYETHYL)THEOPHYLLINE

7-(2-HYDROXYETHYL)THEOPHYLLINE

Product Name
7-(2-HYDROXYETHYL)THEOPHYLLINE
CAS No.
519-37-9
Chemical Name
7-(2-HYDROXYETHYL)THEOPHYLLINE
Synonyms
ETOFYLLINE;Etofylline CRS;Oxyethyltheophylline;7-(BETA-HYDROXYETHYL)THEOPHYLLINE;7-(2-Hydroxyethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;KT 200G;Cordalin;Etofyllin;NSC 113373;Oxyphyllin
CBNumber
CB2333122
Molecular Formula
C9H12N4O3
Formula Weight
224.22
MOL File
519-37-9.mol
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7-(2-HYDROXYETHYL)THEOPHYLLINE Property

Melting point:
163°C
Boiling point:
365.61°C (rough estimate)
Density 
1.3055 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: Solutions may be stored for several days at 4°C.soluble
form 
solid
pka
14.48±0.10(Predicted)
color 
white
Water Solubility 
2.991g/L(temperature not stated)
Merck 
14,3878
CAS DataBase Reference
519-37-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-36/37-26
WGK Germany 
3
RTECS 
XH5850000
HS Code 
2939590000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2541
Product name
Theophylline Related Compound F
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
100MG
Price
$508
Updated
2024/03/01
Sigma-Aldrich
Product number
1653060
Product name
Theophylline Related Compound F
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1720
Updated
2024/03/01
Sigma-Aldrich
Product number
H9006
Product name
7-(β-Hydroxyethyl)theophylline
Purity
solid
Packaging
25g
Price
$104
Updated
2023/01/07
Sigma-Aldrich
Product number
PHR2588
Product name
Theophylline Related Compound F
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
100MG
Price
$443
Updated
2022/05/15
TCI Chemical
Product number
H0402
Product name
7-(2-Hydroxyethyl)theophylline
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$88
Updated
2024/03/01
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7-(2-HYDROXYETHYL)THEOPHYLLINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Duolip,Merckle,W. Germany,1981

Uses

Useful synthetic intermediate in the preparation of 7-substituted xanthines.

Uses

Cardiac analeptic;Phosphodiesterase inhibitor

Uses

An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.

Definition

ChEBI: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione is an oxopurine.

Manufacturing Process

107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.

Therapeutic Function

Antihyperlipidemic

Biochem/physiol Actions

Pharmacological profile similar to theophylline.

7-(2-HYDROXYETHYL)THEOPHYLLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-(2-HYDROXYETHYL)THEOPHYLLINE Suppliers

Americas 1 Belgium 1 Canada 3 China 105 Czech Republic 1 Europe 3 France 3 Germany 3 India 49 Japan 2 South Africa 1 Spain 1 Switzerland 2 United Kingdom 8 United States 39 Venezuela 1 Global 223
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
Alexis Corporation
Tel
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Fax
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Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74
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View Lastest Price from 7-(2-HYDROXYETHYL)THEOPHYLLINE manufacturers

Career Henan Chemical Co
Product
7-(2-Hydroxyethyl)theophylline 519-37-9
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98%HPLC
Supply Ability
g/kg/ton
Release date
2020-02-01

519-37-9, 7-(2-HYDROXYETHYL)THEOPHYLLINERelated Search:

Tazifylline PROXYPHYLLINE Theophylline-7-acetic acid Diprophylline Doxofylline Xanthinol nicotinate ETOFYLLINE CLOFIBRATE 7-(2-HYDROXYETHYL)THEOPHYLLINE Theophylline 1,3-DIMETHYL-7-(OXIRAN-2-YLMETHYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-CHLORO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-[2-(4-CHLOROPHENOXY)ETHYL]-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE ETHYL 2-(8-CHLORO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-8-MORPHOLINO-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE ETHYL 2-(8-BROMO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE 8-BROMO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-8-NITRO-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

  • ETOFYLLINE EPE(CRM STANDARD)
  • ETOFYLLINE MM(CRM STANDARD)
  • 7-(2-HYDROXYETHYL)THEOPHYLLINE 98+%
  • ETOFYLLINE (BETA-HYDROXYETHYLTHEOPHYLLINE)
  • Phyllocormin
  • ETOFYLLINE
  • BETA-HYDROXYETHYLTHEOPHYLLINE
  • BIOPHYLLINE
  • THEOPHYLLINE, 7-(BETA-HYDROXYETHYL)
  • 7-(2-hydroxyethyl)-1,3-dimethyl-purine-2,6-dione
  • 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione
  • KT 200G
  • NSC 113373
  • Oxyethophylline
  • Oxyphyllin
  • 7-(2-Hydroxyethyl)-1,3-diMethyl-3,7-dihydro-1H-purine-2,6-dione,97%
  • 7-(2-Hydroxyethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
  • Theophylline EP Impurity F
  • Theophylline Related Compound F
  • 7-(A-HYDROXYETHYL)THEOPHYLLINE
  • 7-(BETA-HYDROXYETHYL)THEOPHYLLINE
  • 7-(2-HYDROXYETHYL)THEOPHYLLINE
  • 1,3-DIMETHYL-7-(BETA-HYDROXYETHYL)XANTHINE
  • 1,3-DIMETHYL-7-[2-HYDROXYETHYL]-XANTHINE
  • 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-
  • 3,7-Dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione
  • 3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1h-purine-6-dione
  • oxphylline(amido)
  • Oxyaethyltheophyllin
  • Oxyethyltheophylline
  • Oxyphylline
  • Oxytheonyl
  • Phyllocormin N
  • phyllocorminn
  • Sklerodormal
  • Soluphylline
  • Theophylline, 7-(2-hydroxyethyl)-
  • Etofyllin
  • Diprophylline Impurity 3（Diprophylline EP Impurity C）
  • Theophylline-ethylenediamine Impurity 6（Theophylline-ethylenediamine EP Impurity F）
  • Diprophylline EP Impurity C
  • 7-(Hydroxyethyl)theophylline
  • 7-Theophyllineethanol
  • Aethophyllinum
  • Ascorphylline
  • b-hydroxyethyltheophylline
  • Cordalin
  • Corophyllin-N
  • Dilaphyllin
  • Frekaphyllin
  • Hydroxyethyl theophyline
  • Hydroxyethyltheophylline
  • Oxphylline
  • Oxphylline (Amido)
  • 7-(2-Hydroxyethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • 7-(2-Hydroxyethyl)-1,3-dimethylxanthine
  • 7-(2-hydroxyethyl)-theophyllin
  • Hydroxuethyl theophylline