3'-Azido-3'-deoxy-2-thiouridine
- Product Name
- 3'-Azido-3'-deoxy-2-thiouridine
- CAS No.
- 2305416-00-4
- Chemical Name
- 3'-Azido-3'-deoxy-2-thiouridine
- Synonyms
- 3’-Azido-3’-deoxy-2-thiouridine;3'-Azido-3'-deoxy-2-thiouridine;1-((2R,3R,4S,5S)-4-azido-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
- CBNumber
- CB23334230
- Molecular Formula
- C9H11N5O4S
- Formula Weight
- 285.28
- MOL File
- 2305416-00-4.mol
3'-Azido-3'-deoxy-2-thiouridine Chemical Properties,Usage,Production
Uses
3’-Azido-3’-deoxy-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-2-thiouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
3'-Azido-3'-deoxy-2-thiouridine Preparation Products And Raw materials
Raw materials
Preparation Products
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