ARN-3236

Product Name: ARN-3236
CAS No.: 1613710-01-2
Chemical Name: ARN-3236
Synonyms: ARN-3236;ARN-3236 (ARN3236);ARN-3236, 10 mM in DMSO;ARN-3236; ARN 3236; ARN3236;3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-;3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE;inhibit,ARN3236,Salt-inducible Kinase (SIK),ARN-3236,ARN 3236,Inhibitor
CBNumber: CB23339851
Molecular Formula: C19H16N2O2S
Formula Weight: 336.41
MOL File: 1613710-01-2.mol

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ARN-3236 Property

Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:65.67(Max Conc. mg/mL);195.21(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.95(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);89.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
form: A crystalline solid
pka: 13.33±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3802
Product name: ARN-3236
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $126.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3802
Product name: ARN-3236
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $534
Updated: 2025/07/31

ChemScene

Product number: CS-0079380
Product name: ARN-3236
Purity: 99.60%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0079380
Product name: ARN-3236
Purity: 99.60%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0079380
Product name: ARN-3236
Purity: 99.60%
Packaging: 2mg
Price: $100
Updated: 2021/12/16

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ARN-3236 Chemical Properties,Usage,Production

Uses

ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity[1][2].

Biological Activity

ARN-3236 is an orally active, ATP-competitive, SIK2-selective salt-inducible kinase inhibitor (IC50 = 21.63 nM/SIK1, <1 nM/SIK2, 6.63 nM/SIK3) th at suppresses cellular SIK2 activity (by 58% at 1 μM; SKOv3-SIK2 cells, 48 h) with high selectivity over >456 kinases. ARN-3236 effectively suppresses SIK2-dependent growth of ovarian cancer cultures (IC50 = 0.8-2.6 μM in 10 lines, 72 h) and in murine xenograft models in vivo (30, 60, 100 mg/kg/day p.o.). In addition, ARN-3236 sensitizes ovarian cancer cells to paclitaxel in vitro and in vivo. ARN-3236 completes the SIK1-selective HG-9-91-01 (SIK1/2/3 IC50 = 0.6/6.6/9.6 nM) in probing SIKs-mediated cellular signaling events.

in vivo

ARN-3236 (60 mg/kg, orally) sensitizes ovarian cancer to NSC 125973 in vivo^[2].

Animal Model:	SKOv3ip-bearing mice and OVCAR8-bearing mice^[2].
Dosage:	60 mg/kg.
Administration:	Orally once daily for 3 weeks (SKOv3ip-bearing mice) and 4 weeks (OVCAR8-bearing mice).
Result:	Sensitized ovarian cancer to NSC 125973.

IC 50

SIK2: <1 nM (IC₅₀); SIK1: 21.63 nM (IC₅₀); SIK3: 6.63 nM (IC₅₀)

storage

Store at -20°C

References

[1] Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99(5):711-21. DOI:10.1189/jlb.2A0715-307R
[2] Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954. DOI:10.1158/1078-0432.CCR-16-1562

ARN-3236 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARN-3236 Suppliers

China 55 United States 6 Global 61

Shanghai Lollane Biological Technology Co.,Ltd.

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1613710-01-2, ARN-3236Related Search:

ARN-3236

3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE

ARN-3236; ARN 3236; ARN3236

1H-Pyrrolo[2,3-b]pyridine, 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-

3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine

inhibit,ARN3236,Salt-inducible Kinase (SIK),ARN-3236,ARN 3236,Inhibitor

ARN-3236, 10 mM in DMSO

ARN-3236 (ARN3236)

1613710-01-2