ChemicalBook > CAS DataBase List > ARN-3236

ARN-3236

Product Name
ARN-3236
CAS No.
1613710-01-2
Chemical Name
ARN-3236
Synonyms
ARN-3236;ARN-3236, 10 mM in DMSO;ARN-3236; ARN 3236; ARN3236;3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-;3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE;inhibit,ARN3236,Salt-inducible Kinase (SIK),ARN-3236,ARN 3236,Inhibitor
CBNumber
CB23339851
Molecular Formula
C19H16N2O2S
Formula Weight
336.41
MOL File
1613710-01-2.mol
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ARN-3236 Property

Density 
1.278±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:65.67(Max Conc. mg/mL);195.21(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.95(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);89.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
form 
A crystalline solid
pka
13.33±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0079380
Product name
ARN-3236
Purity
99.60%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0079380
Product name
ARN-3236
Purity
99.60%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0079380
Product name
ARN-3236
Purity
99.60%
Packaging
2mg
Price
$100
Updated
2021/12/16
Axon Medchem
Product number
Axon3041
Product name
ARN3236
Purity
98%
Packaging
5mg
Price
$104.5
Updated
2021/12/16
ChemScene
Product number
CS-0079380
Product name
ARN-3236
Purity
99.60%
Packaging
50mg
Price
$550
Updated
2021/12/16
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ARN-3236 Chemical Properties,Usage,Production

Biological Activity

ARN-3236 is an orally active, ATP-competitive, SIK2-selective salt-inducible kinase inhibitor (IC50 = 21.63 nM/SIK1, <1 nM/SIK2, 6.63 nM/SIK3) th at suppresses cellular SIK2 activity (by 58% at 1 μM; SKOv3-SIK2 cells, 48 h) with high selectivity over >456 kinases. ARN-3236 effectively suppresses SIK2-dependent growth of ovarian cancer cultures (IC50 = 0.8-2.6 μM in 10 lines, 72 h) and in murine xenograft models in vivo (30, 60, 100 mg/kg/day p.o.). In addition, ARN-3236 sensitizes ovarian cancer cells to paclitaxel in vitro and in vivo. ARN-3236 completes the SIK1-selective HG-9-91-01 (SIK1/2/3 IC50 = 0.6/6.6/9.6 nM) in probing SIKs-mediated cellular signaling events.

storage

Store at -20°C

ARN-3236 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARN-3236 Suppliers

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1613710-01-2, ARN-3236Related Search:


  • ARN-3236
  • 3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE
  • ARN-3236; ARN 3236; ARN3236
  • 1H-Pyrrolo[2,3-b]pyridine, 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-
  • 3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine
  • inhibit,ARN3236,Salt-inducible Kinase (SIK),ARN-3236,ARN 3236,Inhibitor
  • ARN-3236, 10 mM in DMSO
  • 1613710-01-2