ARN-3236

Product Name: ARN-3236
CAS No.: 1613710-01-2
Chemical Name: ARN-3236
Synonyms: ARN-3236;ARN-3236, 10 mM in DMSO;ARN-3236; ARN 3236; ARN3236;3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-;3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE;inhibit,ARN3236,Salt-inducible Kinase (SIK),ARN-3236,ARN 3236,Inhibitor
CBNumber: CB23339851
Molecular Formula: C19H16N2O2S
Formula Weight: 336.41
MOL File: 1613710-01-2.mol

More

Less

ARN-3236 Property

Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:65.67(Max Conc. mg/mL);195.21(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.95(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);89.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
form: A crystalline solid
pka: 13.33±0.40(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0079380
Product name: ARN-3236
Purity: 99.60%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0079380
Product name: ARN-3236
Purity: 99.60%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0079380
Product name: ARN-3236
Purity: 99.60%
Packaging: 2mg
Price: $100
Updated: 2021/12/16

Axon Medchem

Product number: Axon3041
Product name: ARN3236
Purity: 98%
Packaging: 5mg
Price: $104.5
Updated: 2021/12/16

ChemScene

Product number: CS-0079380
Product name: ARN-3236
Purity: 99.60%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

More

Less

ARN-3236 Chemical Properties,Usage,Production

Biological Activity

ARN-3236 is an orally active, ATP-competitive, SIK2-selective salt-inducible kinase inhibitor (IC50 = 21.63 nM/SIK1, <1 nM/SIK2, 6.63 nM/SIK3) th at suppresses cellular SIK2 activity (by 58% at 1 μM; SKOv3-SIK2 cells, 48 h) with high selectivity over >456 kinases. ARN-3236 effectively suppresses SIK2-dependent growth of ovarian cancer cultures (IC50 = 0.8-2.6 μM in 10 lines, 72 h) and in murine xenograft models in vivo (30, 60, 100 mg/kg/day p.o.). In addition, ARN-3236 sensitizes ovarian cancer cells to paclitaxel in vitro and in vivo. ARN-3236 completes the SIK1-selective HG-9-91-01 (SIK1/2/3 IC50 = 0.6/6.6/9.6 nM) in probing SIKs-mediated cellular signaling events.

storage

Store at -20°C

ARN-3236 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ARN-3236 Suppliers

China 41 United States 5 Global 46

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4569
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1005
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9805
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2948
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1925
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

1613710-01-2, ARN-3236Related Search:

ARN-3236

3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE

ARN-3236; ARN 3236; ARN3236

1H-Pyrrolo[2,3-b]pyridine, 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-

3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine

inhibit,ARN3236,Salt-inducible Kinase (SIK),ARN-3236,ARN 3236,Inhibitor

ARN-3236, 10 mM in DMSO

1613710-01-2