ChemicalBook > CAS DataBase List > (R)-5,7-difluorochroman-4-ol

(R)-5,7-difluorochroman-4-ol

Product Name
(R)-5,7-difluorochroman-4-ol
CAS No.
1270294-05-7
Chemical Name
(R)-5,7-difluorochroman-4-ol
Synonyms
(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan side chain;Tegoprazan ImpuritiesC;(R)-5, 7-difluorobenzopyrane-4-ol;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-;[2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine]
CBNumber
CB23354564
Molecular Formula
C9H8F2O2
Formula Weight
186.16
MOL File
1270294-05-7.mol
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(R)-5,7-difluorochroman-4-ol Property

Boiling point:
228.4±40.0 °C(Predicted)
Density 
1.402±0.06 g/cm3(Predicted)
pka
13.09±0.20(Predicted)
InChI
InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1
InChIKey
HGTYMLFMXKYIQW-SSDOTTSWSA-N
SMILES
C1OC2=CC(F)=CC(F)=C2[C@H](O)C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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(R)-5,7-difluorochroman-4-ol Chemical Properties,Usage,Production

Uses

(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].

Production Methods

Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].

References

[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.

(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-5,7-difluorochroman-4-ol manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
(R)-5,7-difluorochroman-4-ol 1270294-05-7
Price
US $0.10/kg
Min. Order
0.005kg
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-15
Zhengzhou Anbu Chem Co.,Ltd
Product
(R)-5,7-difluorochroman-4-ol 1270294-05-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KGS
Release date
2023-06-19
Hangzhou ICH Biofarm Co., Ltd
Product
(R)-5,7-difluorochroman-4-ol 1270294-05-7
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99.0%min
Supply Ability
2000kg
Release date
2023-06-09

1270294-05-7, (R)-5,7-difluorochroman-4-olRelated Search:

1-benzyl-2-methyl-1H-imidazole-carbaldehyde Dimethoxymethane 1H-Benzimidazole-6-carboxylic acid, 4-hydroxy-2-methyl-1-(phenylmethyl)-, ethyl ester 5,7-difluorochroman-4-one (Dimethylamino)acetaldehyde Dimethyl Acetal 2-Aminobiphenyl 1-(piperidine-4-carbonyl)piperidine-4-carboxylic acid hydrochloride Butanedioic acid, 2-[[2-methyl-1-(phenylmethyl)-1H-imidazol-5-yl]methylene]-, 1-ethyl ester, (2E)- 1H-Benzimidazole-6-carboxamide, 4-hydroxy-N,N,2-trimethyl-1-(phenylmethyl)- Benzoic acid, 4-[[4-(aminocarbonyl)-1-piperidinyl]methyl]- Revefenacin Impurity 16 1-benzyl-4-hydroxy-2-methyl-1H-benzo[d]imidazole-6-carboxylic acid Dibenzofuran

  • 2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-
  • (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol
  • R-5,7-difluorobenzo dihydropyran-4-ol
  • Tegoprazan Impurity 11
  • [2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine]
  • (R)-5, 7-difluorobenzopyrane-4-ol
  • Tegoprazan side chain
  • Tegoprazan ImpuritiesC
  • 1270294-05-7
  • API