ChemicalBook > CAS DataBase List > ST034307

ST034307

Product Name: ST034307
CAS No.: 133406-29-8
Chemical Name: ST034307
Synonyms: ST034307;ST034307 ，S0451;ST034307 >=98% (HPLC);ST034307, 10 mM in DMSO;ST034307;ST-034307;ST 034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase
CBNumber: CB23356179
Molecular Formula: C10H4Cl4O2
Formula Weight: 297.95
MOL File: 133406-29-8.mol

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ST034307 Property

Boiling point:: 329.1±42.0 °C(Predicted)
Density: 1.674±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
form: solid
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21777
Product name: ST034307
Purity: ≥95%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 21777
Product name: ST034307
Purity: ≥95%
Packaging: 5mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 21777
Product name: ST034307
Purity: ≥95%
Packaging: 10mg
Price: $264
Updated: 2024/03/01

Cayman Chemical

Product number: 21777
Product name: ST034307
Purity: ≥95%
Packaging: 25mg
Price: $576
Updated: 2024/03/01

Tocris

Product number: 6271
Product name: ST034307
Purity: ≥98%(HPLC)
Packaging: 10
Price: $141
Updated: 2021/12/16

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ST034307 Chemical Properties,Usage,Production

Description

ST-034307 (133406-29-8) is a?novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. ?It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3?Displays analgesic properties in a mouse model of inflammatory pain.1?A useful tool for exploring the involvement of AC1 in cellular signalling.2

Uses

ST 034307 is a useful intermediate.

in vivo

ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E₅₀) value for analgesia of 0.28 μg in the mouse pain model^[1].

storage

Store at -20°C

References

[1] TARSIS F. BRUST. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties[J]. Science Signaling, 2017, 10 467. DOI:10.1126/scisignal.aah5381
[2] ZHENG JIANG. Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.[J]. Journal of Chemical Theory and Computation, 2018: 652-664.e12. DOI:10.1016/j.cell.2018.08.055
[3] WATTS V J. Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain[J]. Neuropsychopharmacology, 2017, 43 1: 215-216. DOI:10.1038/npp.2017.190

ST034307 Preparation Products And Raw materials

Raw materials

Preparation Products

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ST034307 Suppliers

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133406-29-8, ST034307Related Search:

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ST034307

6-chloro-2-(trichloromethyl)-4H-chromen-4-one

ST034307;ST-034307;ST 034307

6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-

ST034307 >=98% (HPLC)

Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase

ST034307, 10 mM in DMSO

ST034307 ，S0451

133406-29-8