ST034307
- Product Name
- ST034307
- CAS No.
- 133406-29-8
- Chemical Name
- ST034307
- Synonyms
- ST034307;ST034307 >=98% (HPLC);ST034307;ST-034307;ST 034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase
- CBNumber
- CB23356179
- Molecular Formula
- C10H4Cl4O2
- Formula Weight
- 297.95
- MOL File
- 133406-29-8.mol
ST034307 Property
- Boiling point:
- 329.1±42.0 °C(Predicted)
- Density
- 1.674±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
- form
- solid
- color
- Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21777
- Product name
- ST034307
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 21777
- Product name
- ST034307
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 21777
- Product name
- ST034307
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $264
- Updated
- 2024/03/01
- Product number
- 21777
- Product name
- ST034307
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $576
- Updated
- 2024/03/01
- Product number
- 6271
- Product name
- ST034307
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $590
- Updated
- 2021/12/16
ST034307 Chemical Properties,Usage,Production
Description
ST-034307 (133406-29-8) is a?novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. ?It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3?Displays analgesic properties in a mouse model of inflammatory pain.1?A useful tool for exploring the involvement of AC1 in cellular signalling.2
Uses
ST 034307 is a useful intermediate.
storage
Store at -20°C
References
1) Brust?et al.?(2017),?Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal,?10?eaah5381 2) Jiang?et al,?(2018),?Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells;. Cell?175?652 3) Watts (2018),?Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain;?Neuropsychopharmacology?43?215
ST034307 Preparation Products And Raw materials
Raw materials
Preparation Products
ST034307 Suppliers
- Tel
- -2408801818 18621020637
- sales@sunsynpharma.com
- Country
- China
- ProdList
- 289
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 15502154572
- Fax
- -
- yuben012@sina.com
- Country
- China
- ProdList
- 508
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 0371-55289822 18737195735
- Fax
- QQ:483339295
- 483339295@qq.com
- Country
- China
- ProdList
- 7118
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ：2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29977
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32957
- Advantage
- 60
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6829
- Advantage
- 58
- Tel
- --
- Fax
- --
- lyn@biopike.com.cn
- Country
- CHINA
- ProdList
- 6629
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3007606172@qq.com
- Country
- CHINA
- ProdList
- 6002
- Advantage
- 58