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EPAC 5376753

Product Name
EPAC 5376753
CAS No.
302826-61-5
Chemical Name
EPAC 5376753
Synonyms
EPAC 5376753;4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]dihydro-2-thioxo-
CBNumber
CB38054392
Molecular Formula
C15H8Cl2N2O3S
Formula Weight
367.21
MOL File
302826-61-5.mol
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EPAC 5376753 Property

Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
pka
4.86±0.20(Predicted)
form 
solid
color 
Orange-red
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

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EPAC 5376753 Chemical Properties,Usage,Production

Description

EPAC 5376753 (302826-61-5) is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2

References

1) Brown et al. (2014), Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors; J. Biol. Chem., 289 29148 2) Parnell et al. (2015), The future of EPAC-targeted therapies: agonism versus antagonism; Trends Pharmacol. Sci., 36 203

EPAC 5376753 Preparation Products And Raw materials

Raw materials

Preparation Products

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EPAC 5376753 Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24648
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38463
Advantage
58

302826-61-5, EPAC 5376753Related Search:


  • EPAC 5376753
  • 4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]dihydro-2-thioxo-
  • 302826-61-5