8-pCPT-2-O-Me-cAMP-AM
- Product Name
- 8-pCPT-2-O-Me-cAMP-AM
- CAS No.
- 1152197-23-3
- Chemical Name
- 8-pCPT-2-O-Me-cAMP-AM
- Synonyms
- 8-pCPT-2-O-Me-cAMP-AM;8 pCPT 2 O Me cAMP AM,8pCPT2OMecAMPAM;8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-(acetyloxy)methyl)-cyclic monophosphate;Adenosine, 8-[(4-chlorophenyl)thio]-2'-O-methyl-, cyclic 3',5'-[(acetyloxy)methyl phosphate]
- CBNumber
- CB63037111
- Molecular Formula
- C20H21ClN5O8PS
- Formula Weight
- 557.9
- MOL File
- 1152197-23-3.mol
8-pCPT-2-O-Me-cAMP-AM Property
- Boiling point:
- 757.2±70.0 °C(Predicted)
- Density
- 1.80±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 50 mg/ml).
- pka
- 2.88±0.10(Predicted)
- form
- solid
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- SML3072
- Product name
- 8-pCPT-2′-O-Me-cAMP-AM
- Purity
- ≥98% (HPLC)
- Packaging
- 1UMO
- Price
- $394
- Updated
- 2023/06/20
- Product number
- C781488
- Product name
- 8-pCPT-2’-O-Me-cAMP-AM
- Packaging
- 100g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- B5737
- Product name
- 8-pCPT-2-O-Me-cAMP-AM
- Packaging
- 100ug
- Price
- $215
- Updated
- 2021/12/16
8-pCPT-2-O-Me-cAMP-AM Chemical Properties,Usage,Production
Description
8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator.1?Induces RAP1 activation and insulin secretion in pancreatic beta cell lines.2-5?Induces vascular relaxation in rat mesenteric artery.6?The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2′-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the acetoxymethyl ester and reduce cell permeability.
Uses
8-pCPT-2-O-Me-cAMP-AM (cas# 1152197-23-3) is a useful research chemical.8-pCPT-2-O-Me-cAMP-AM was used in the study to discover potential insulin secretagogue properties of an acetoxymethyl that activates guanine nucleotide exchange factors.
storage
Store at -20°C
References
1) Vliem?et al. (2008),?8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue; Chem. Biochem.,?9?2052 2) Chepurny?et al. (2009),?Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2′-O-Me-cAMP-AM; J. Biol. Chem.,?284?10728 3) Kelley?et al. (2009),?Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM; Islets,?1?260 4) Chepurny?et al. (2010),?PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans; Am. J. Physiol. Endocrinol. Metab.,?298?E622 5) Dzhura?et al. (2011),?Phospholipase C-ε links EPAC2 activation to the potentiation of glucose stimulated insulin secretion from mouse islets of Langerhans; Islets,?3?121 6) Roberts?et al. (2013),?Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery; J. Physiol.,?591?5107
8-pCPT-2-O-Me-cAMP-AM Preparation Products And Raw materials
Raw materials
Preparation Products
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