ChemicalBook > CAS DataBase List > Ibudilast

Ibudilast

Product Name
Ibudilast
CAS No.
50847-11-5
Chemical Name
Ibudilast
Synonyms
Ketas;KC-404;AV 411;MN-166;CS-351;Pinatos;Eyevinal;budilast;IBUDILAST;lbudilast
CBNumber
CB0145945
Molecular Formula
C14H18N2O
Formula Weight
230.31
MOL File
50847-11-5.mol
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Ibudilast Property

Melting point:
53-54°C
Boiling point:
175°C/7.5mmHg(lit.)
Density 
1.09
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL, soluble
form 
solid
pka
1.22±0.30(Predicted)
color 
white
Merck 
14,4879
InChIKey
ZJVFLBOZORBYFE-UHFFFAOYSA-N
CAS DataBase Reference
50847-11-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
UR0711200
Toxicity
LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I0157
Product name
Ibudilast
Purity
≥99% (HPLC), solid
Packaging
10mg
Price
$253
Updated
2020/08/18
Sigma-Aldrich
Product number
I0157
Product name
Ibudilast
Purity
≥99% (HPLC), solid
Packaging
50mg
Price
$967
Updated
2020/08/18
TCI Chemical
Product number
I0740
Product name
Ibudilast
Purity
>98.0%(HPLC)(T)
Packaging
20mg
Price
$195
Updated
2020/06/24
TCI Chemical
Product number
I0740
Product name
Ibudilast
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$651
Updated
2020/06/24
Cayman Chemical
Product number
14832
Product name
Ibudilast
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2020/06/24
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Ibudilast Chemical Properties,Usage,Production

Description

Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.

Chemical Properties

White Solid

Originator

Kyorin (Japan)

Uses

a phosphodiesterase inhibitor with anti-inflammatory activity

Uses

Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

Uses

A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)

brand name

Ketas

Biological Activity

Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Ibudilast Preparation Products And Raw materials

Raw materials

Preparation Products

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Ibudilast Suppliers

Shandong Chenxi Pharmaceutical Co., Ltd.
Tel
0531-88803416-
Fax
0531-88803416
Email
sales@chemedpharma.com;
Country
China
ProdList
115
Advantage
58
JinanGongchuang Pharmaceutical Technology Co. Ltd..
Tel
0531-88065293-
Fax
0531-88065293
Email
3166282224@qq.com
Country
China
ProdList
36
Advantage
58
Suizhou Jiake Biological Engineering Co., Ltd.
Tel
0722-36329898- ;0722-3632789-
Fax
0722-3255139
Email
2286801987@qq.com;25949463910@qq.com
Country
China
ProdList
107
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40268
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15880
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5953
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
010-57411839-
Fax
021-55236763
Email
bjsales@hwrkchemical.com
Country
China
ProdList
18708
Advantage
55
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View Lastest Price from Ibudilast manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
Ibudilast 50847-11-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2019-07-04
Shaanxi Dideu Medichem Co. Ltd
Product
Ibudilast 50847-11-5
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08
career henan chemical co
Product
Ibudilast 50847-11-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KG
Release date
2019-09-04

50847-11-5, IbudilastRelated Search:


  • IBUDILAST
  • IBUDILAST-D7
  • KC-404
  • 1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]
  • 3-Isobutyryl-2-isopropy-lpyrazolo[1,5-α]pyridine
  • Ketas
  • Eyevinal
  • 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone
  • Pinatos
  • Ibudilast,2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404
  • 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-Methylpropan-1-one
  • AV 411
  • Ibudilast (KC-404)
  • MN-166
  • CS-351
  • -Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
  • 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE
  • 2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine
  • 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE
  • Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
  • 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
  • Ibudilast, >=98%
  • budilast
  • 1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]
  • 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone
  • 2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon
  • 5-a)pyridine,3-isobutyryl-2-isopropyl-pyrazolo(
  • lbudilast
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, Ketas
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-α]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-α]pyridine, KC-404, Ketas
  • Ibudilast&gt
  • 50847-11-5
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • G Proteins and Cyclic Nucleotides
  • Phosphodiesterase Inhibitors
  • Cyclic Nucleotide Metabolism
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Cyclic Nucleotide related
  • Amines
  • Heterocycles
  • API