ChemicalBook > CAS DataBase List > Ibudilast

Ibudilast

Product Name
Ibudilast
CAS No.
50847-11-5
Chemical Name
Ibudilast
Synonyms
Ketas;KC-404;AV 411;Pinatos;budilast;Eyevinal;lbudilast;IBUDILAST;IBUDILAST-D7;Ibudilast, >=98%
CBNumber
CB0145945
Molecular Formula
C14H18N2O
Formula Weight
230.31
MOL File
50847-11-5.mol
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Ibudilast Property

Melting point:
53-54°C
Boiling point:
175°C/7.5mmHg(lit.)
Density 
1.09
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL, soluble
form 
solid
color 
white
Merck 
14,4879
InChIKey
ZJVFLBOZORBYFE-UHFFFAOYSA-N
CAS DataBase Reference
50847-11-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
UR0711200
Toxicity
LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I0157
Product name
Ibudilast
Purity
≥99% (HPLC), solid
Packaging
10mg
Price
$243
Updated
2018/11/13
Sigma-Aldrich
Product number
I0157
Product name
Ibudilast
Purity
≥99% (HPLC), solid
Packaging
50mg
Price
$931
Updated
2018/11/13
TCI Chemical
Product number
I0740
Product name
Ibudilast
Purity
>98.0%(HPLC)(T)
Packaging
20mg
Price
$154
Updated
2018/11/22
TCI Chemical
Product number
I0740
Product name
Ibudilast
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$516
Updated
2018/11/22
Cayman Chemical
Product number
14832
Product name
Ibudilast
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2018/11/13
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Ibudilast Chemical Properties,Usage,Production

Description

Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.

Chemical Properties

White Solid

Originator

Kyorin (Japan)

Uses

a phosphodiesterase inhibitor with anti-inflammatory activity

Uses

Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

Uses

A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)

brand name

Ketas

Biological Activity

Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Ibudilast Preparation Products And Raw materials

Raw materials

Preparation Products

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Ibudilast Suppliers

Shandong Chenxi Pharmaceutical Co., Ltd.
Tel
0531-88803416 13153166250
Fax
0531-88803416
Email
sales@chemedpharma.com
Country
China
ProdList
55
Advantage
58
JinanGongchuang Pharmaceutical Technology Co. Ltd..
Tel
13287783460
Fax
+86 (531) 8806-5293
Email
3166282224@qq.com
Country
China
ProdList
31
Advantage
58
Suizhou Jiake Biological Engineering Co., Ltd.
Tel
0722-3632989;18008664499;0722-3632789;18008664168
Fax
0722-3255139 QQ:2286801987;2549463910
Email
2286801987@qq.com
Country
China
ProdList
100
Advantage
58
Beijing Huikang Boyuan Chemical Tech Co., Ltd
Tel
010-68862197
Fax
010-68882204
Email
bjhkby@126.com
Country
China
ProdList
100
Advantage
61
Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
J & K SCIENTIFIC LTD.
Tel
400-666-7788 +86-10-82848833
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
Fax
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)
Email
sh@meryer.com
Country
China
ProdList
40269
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
86-21-50328103 * 801、802、803、804 Mobile:18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15881
Advantage
69
Chembest Research Laboratories Limited
Tel
+86(0)21-20908456
Fax
+86(0)21-58180499
Email
sales@biochembest.com; market@biochembest.com
Country
China
ProdList
5996
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
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View Lastest Price from Ibudilast manufacturers

career henan chemical co
Product
Ibudilast 50847-11-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KG
Release date
2019-09-04
Hebei Guanlang Biotechnology Co., Ltd.
Product
Ibudilast 50847-11-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2019-07-04
career henan chemical co
Product
Ibudilast 50847-11-5
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-15

50847-11-5, IbudilastRelated Search:


  • 2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine
  • 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE
  • 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE
  • Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
  • 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
  • Ibudilast, >=98%
  • budilast
  • 1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]
  • 2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon
  • 5-a)pyridine,3-isobutyryl-2-isopropyl-pyrazolo(
  • lbudilast
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, Ketas
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-α]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-α]pyridine, KC-404, Ketas
  • 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone
  • IBUDILAST
  • IBUDILAST-D7
  • KC-404
  • 1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]
  • 3-Isobutyryl-2-isopropy-lpyrazolo[1,5-α]pyridine
  • Ketas
  • Eyevinal
  • 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone
  • Pinatos
  • Ibudilast,2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404
  • 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-Methylpropan-1-one
  • AV 411
  • Ibudilast (KC-404)
  • 50847-11-5
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Phosphodiesterase Inhibitors
  • Cyclic Nucleotide Metabolism
  • G Proteins and Cyclic Nucleotides
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Cyclic Nucleotide related
  • -
  • Amines
  • Heterocycles
  • API