ChemicalBook > CAS DataBase List > Ibudilast

Ibudilast

Product Name
Ibudilast
CAS No.
50847-11-5
Chemical Name
Ibudilast
Synonyms
Ketas;KC-404;AV 411;MN-166;CS-351;Pinatos;Eyevinal;budilast;IBUDILAST;lbudilast
CBNumber
CB0145945
Molecular Formula
C14H18N2O
Formula Weight
230.31
MOL File
50847-11-5.mol
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Ibudilast Property

Melting point:
53-54°C
Boiling point:
175°C/7.5mmHg(lit.)
Density 
1.09
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: 28 mg/mL, soluble
form 
solid
pka
1.22±0.30(Predicted)
color 
white
Merck 
14,4879
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI
InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
InChIKey
ZJVFLBOZORBYFE-UHFFFAOYSA-N
SMILES
C(C1=C2N(N=C1C(C)C)C=CC=C2)(=O)C(C)C
CAS DataBase Reference
50847-11-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
UR0711200
HS Code 
2933.99.8290
Toxicity
LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I0157
Product name
Ibudilast
Purity
≥99% (HPLC), solid
Packaging
10mg
Price
$313
Updated
2024/03/01
Sigma-Aldrich
Product number
I0157
Product name
Ibudilast
Purity
≥99% (HPLC), solid
Packaging
50mg
Price
$1190
Updated
2024/03/01
TCI Chemical
Product number
I0740
Product name
Ibudilast
Purity
>98.0%(HPLC)(T)
Packaging
20mg
Price
$40
Updated
2024/03/01
TCI Chemical
Product number
I0740
Product name
Ibudilast
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
14832
Product name
Ibudilast
Purity
≥98%
Packaging
5mg
Price
$44
Updated
2024/03/01
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Ibudilast Chemical Properties,Usage,Production

Description

Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.

Chemical Properties

White Solid

Originator

Kyorin (Japan)

Uses

a phosphodiesterase inhibitor with anti-inflammatory activity

Uses

Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

Uses

A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)

Definition

ChEBI: Ibudilast is a pyrazolopyridine.

brand name

Ketas

Biological Activity

Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Biochem/physiol Actions

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

in vitro

ibudilast could potently inhibit purified human pde4a, 4b, 4c and 4d with ic50 values at 54, 65, 239 and 166 nm, respectively. ibudilast was also able to effectively block lps-induced tumor necrosis factor and n-formyl-metleu-phe-induced leukotriene b4 biosynthesis in human whole blood [1].

in vivo

rats received a daily oral administration of 10, 30 or 60 mg/kg ibudilast. results showed that in the vehicle-treated animals, white matter lesions and microglial activation occurred in the optic tract, internal capsule and corpus callosum. a low dose of ibudilast failed to suppress the white matter lesions and microglial activation, whereas a dose of either 30 or 60 mg/kg ibudilast ameliorated these lesions [2].

IC 50

54-239 nm

storage

Store at RT

References

1) Kishi et al. (2001), Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall; Cardiovasc. Drug Rev., 19 215 2) Yamazaki et al. (2011), Ibudilast. A mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery; Eur. J. Pharmacol., 650 605 3) Cueva Vargas et al. (2016), The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling.; Neurobiol. Dis., 93 156 4) Mizuno et al. (2004), Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia; Neuropharmacology, 46 404 5) Ledeboer et al. (2007), Ibudilast (AV-411). A class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes; Expert. Opin. Investig. Drugs, 16 935

Ibudilast Preparation Products And Raw materials

Raw materials

Sodium acetate 2-Picoline Isobutyric anhydride

Preparation Products

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View Lastest Price from Ibudilast manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Ibudilast 50847-11-5
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99% HPLC
Supply Ability
10000
Release date
2024-09-17
Dorne Chemical Technology co. LTD
Product
Ibudilast 50847-11-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ibudilast 50847-11-5
Price
US $0.00/Kg/Bag
Min. Order
100g
Purity
99%min
Supply Ability
50kg
Release date
2021-10-25

50847-11-5, IbudilastRelated Search:

Methyl acrylate Isobutyryl chloride Naphazoline hydrochloride METHYL THIOPHENE-2-CARBOXYLATE Isobutyraldehyde Bensulfuron methyl Citric acid monohydrate Kresoxim-methyl Thiophanate-methyl ULINASTATIN Cefazolin 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Methylparaben Cilastatin Imipenem-Cilastatin sodium hydrate Isobutyric anhydride Isobutyric acid Pyridine

  • IBUDILAST
  • IBUDILAST-D7
  • KC-404
  • 1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]
  • 3-Isobutyryl-2-isopropy-lpyrazolo[1，5-α]pyridine
  • Ketas
  • Eyevinal
  • 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone
  • Pinatos
  • Ibudilast,2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404
  • 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-Methylpropan-1-one
  • AV 411
  • Ibudilast (KC-404)
  • MN-166
  • CS-351
  • -Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
  • 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE
  • 2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine
  • 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE
  • Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
  • 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
  • Ibudilast, >=98%
  • budilast
  • 1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]
  • 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone
  • 2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon
  • 5-a)pyridine,3-isobutyryl-2-isopropyl-pyrazolo(
  • lbudilast
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, Ketas
  • 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-α]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-α]pyridine, KC-404, Ketas
  • Ibudilast&gt
  • Ibudilast USP/EP/BP
  • Ibudilast (KC404, AV411， MN166)
  • IbudilastQ: What is Ibudilast Q: What is the CAS Number of Ibudilast Q: What is the storage condition of Ibudilast Q: What are the applications of Ibudilast
  • 50847-11-5
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • G Proteins and Cyclic Nucleotides
  • Phosphodiesterase Inhibitors
  • Cyclic Nucleotide Metabolism
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Cyclic Nucleotide related
  • Amines
  • Heterocycles
  • API