EPAC 5376753

Product Name: EPAC 5376753
CAS No.: 302826-61-5
Chemical Name: EPAC 5376753
Synonyms: EPAC 5376753;5-[[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione;4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]dihydro-2-thioxo-
CBNumber: CB38054392
Molecular Formula: C15H8Cl2N2O3S
Formula Weight: 367.21
MOL File: 302826-61-5.mol

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EPAC 5376753 Property

Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
pka: 4.86±0.20(Predicted)
form: solid
color: Orange-red
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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EPAC 5376753 Chemical Properties,Usage,Production

Description

EPAC 5376753 (302826-61-5) is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2

Uses

EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 μM in Swiss 3T3 cells.

References

[1] LOREN M BROWN. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors.[J]. The Journal of Biological Chemistry, 2014, 289 42: 29148-29157. DOI:10.1074/jbc.m114.569319
[2] EUAN PARNELL S J Y Timothy M Palmer. The future of EPAC-targeted therapies: agonism versus antagonism.[J]. Trends in pharmacological sciences, 2015, 36 4: 203-214. DOI:10.1016/j.tips.2015.02.003

EPAC 5376753 Preparation Products And Raw materials

Raw materials

Preparation Products

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EPAC 5376753 Suppliers

CHINA 11 United States 3 Global 14

Shanghai Dongyang Biotechnology Co., Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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Biosynth Biological Technology (Suzhou) Co Ltd

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Adooq Bioscience LLC

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Shenzhen Zuoke Biotechnology Co., Ltd.

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Absin Bioscience Inc.

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Proteintech China

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302826-61-5, EPAC 5376753Related Search:

Mycophenolic acid ODQ CPI-444 8-pCPT-2-O-Me-cAMP-AM

EPAC 5376753

4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]dihydro-2-thioxo-

5-[[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione

302826-61-5