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Mitiglinide calcium dihydrate

Product Name
Mitiglinide calcium dihydrate
CAS No.
207844-01-7
Chemical Name
Mitiglinide calcium dihydrate
Synonyms
Mitiglinide calcium;KAD-1229 Calcium Hydrate;Mitig;MitigL;inide caL;Miglitol Calcium;KAD-1229 calcium salt;Miglinide Calcium API;S-21403 calcium hydrate;Mitiglinide CalciuM dihydrate
CBNumber
CB2336628
Molecular Formula
C38H52CaN2O8
Formula Weight
704.91
MOL File
207844-01-7.mol
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Mitiglinide calcium dihydrate Property

Melting point:
179-185°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol (Slightly)
form 
Solid
color 
White
InChIKey
QEVLNUAVAONTEW-HNIWBTCONA-L
SMILES
N1(C[C@]2([H])CCCC[C@]2([H])C1)C(=O)C[C@H](CC1=CC=CC=C1)C(=O)O[Ca]OC(=O)[C@@H](CC1=CC=CC=C1)CC(=O)N1C[C@@]2([H])CCCC[C@@]2([H])C1.O.O |&1:2,8,14,29,42,48,r|
CAS DataBase Reference
207844-01-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
K090000
Product name
KAD-1229CalciumHydrate
Packaging
500mg
Price
$230
Updated
2021/12/16
Usbiological
Product number
281061
Product name
KAD-1229 calcium hydrate
Packaging
50mg
Price
$315
Updated
2021/12/16
AK Scientific
Product number
O660
Product name
Mitiglinidecalciumsaltdihydrate
Packaging
25mg
Price
$25
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB24752
Product name
(S)-2-Benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)butyric acid calcium salt hydrate
Packaging
50mg
Price
$47
Updated
2021/12/16
ChemScene
Product number
CS-4570
Product name
Mitiglinidecalciumhydrate
Packaging
100mg
Price
$60
Updated
2021/12/16
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Mitiglinide calcium dihydrate Chemical Properties,Usage,Production

Description

Mitiglinide calcium hydrate (KAD-1229) is an insulinotropic agent. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.

Chemical Properties

White Solid

Uses

KAD-1229 Calcium Hydrate (Mitiglinide calcium dihydrate) could binds to sulfonylurea receptors and inhibits the activity of ATP-sensitive K+ channel in MIN 6 cells. Antidiabetic.

Mechanism of action

Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells, and its early insulin release and short duration of action would be effective in improving postprandial hyperglycemia.

in vivo

Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].

Animal Model:Pregnant Wistar rats (12 weeks)[2]
Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:Oral administration
Result:Dose-dependently suppressed AUCglucose levels.

Mitiglinide calcium dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Mitiglinide calcium dihydrate Suppliers

Canada 1 China 253 India 1 United Kingdom 5 United States 17 Global 277
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Mitiglinide calcium dihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mitiglinide calcium dihydrate 207844-01-7
Price
US $0.00/G
Min. Order
25G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-03
Hebei Chuanghai Biotechnology Co., Ltd
Product
Mitiglinide calcium dihydrate 207844-01-7
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-12-03
Hangzhou ICH Biofarm Co., Ltd
Product
Mitiglinide calcium 207844-01-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0% min
Supply Ability
1000kgs/month
Release date
2023-06-12

207844-01-7, Mitiglinide calcium dihydrateRelated Search:

Diethylstilbestrol Calcium oxide Benzyl alcohol Benzyl bromide Benzyl benzoate Calcium formate Calcium chloride Calcium Propionate [2(S)-cis]-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium sulfate Repaglinide Calcium carbonate cis-Octahydroisoindole CALCIUM ISOBUTYRATE Mivobulin MITIGLINIDE CALCIUM HYDRATE,Mitiglinide calcium,Mitiglinide calcium anhydrous CALCIUM Repaglinide Tablet

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