ChemicalBook > CAS DataBase List > (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide

(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide

Product Name
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
CAS No.
1417997-93-3
Chemical Name
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
Synonyms
22d;HDAC8-IN-1;CS-2693;MDK-7933;INVIVO-7933;HDAC8-IN-22d;HDAC8-IN-1(22d);HDAC8 inhibitor 1;HDAC8 inhibitor 22d;HDAC8-IN-1 ,MDK7933
CBNumber
CB23373154
Molecular Formula
C22H19NO3
Formula Weight
345.39
MOL File
1417997-93-3.mol
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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Property

Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
pka
8.76±0.23(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28832
Product name
HDAC8-IN-1
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
28832
Product name
HDAC8-IN-1
Packaging
25mg
Price
$692
Updated
2024/03/01
Cayman Chemical
Product number
28832
Product name
HDAC8-IN-1
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
28832
Product name
HDAC8-IN-1
Packaging
10mg
Price
$321
Updated
2024/03/01
TRC
Product number
H805220
Product name
(2E)-N-Hydroxy-3-(5-methoxy[1,1'':4'',1''''-terphenyl]-2-yl)-2-propenamide
Packaging
5mg
Price
$275
Updated
2021/12/16
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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Chemical Properties,Usage,Production

Description

HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8; IC50 = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC50s = ≥3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC50s = 7.9, 7.2, and 7 μM, respectively).

Uses

(2E)-N-Hydroxy-3-(5-methoxy[1,1'':4'',1''''-terphenyl]-2-yl)-2-propenamide, is a HDAC8 inhibitor with an IC50 of 27.2 nM.

(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Suppliers

China 61 United States 7 Global 68
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4574
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55
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
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ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
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62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7298
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58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9952
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Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
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Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
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China
ProdList
1925
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Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9578
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60
Angel Pharmatech, Ltd.
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17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3254
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1417997-93-3, (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamideRelated Search:

3-Piperidinecarboxamide, N-methyl-N-(phenylmethyl)-1-[[4-(trifluoromethyl)phenyl]methyl]-, hydrochloride (1:1) N-benzyl-N-Methyl-1-(4-(trifluoroMethyl)benzyl)piperidine-3-carboxaMide

  • (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
  • HDAC8-IN-1
  • HDAC8-IN-1 ,MDK7933
  • MDK-7933
  • HDAC8 inhibitor 1
  • CS-2693
  • HDAC8 inhibitor 22d
  • HDAC8-IN-22d
  • 2-Propenamide, N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-, (2E)-
  • (2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
  • (E)-N-Hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide
  • INVIVO-7933
  • 22d
  • HDAC-8-IN-1,HDAC8IN1,Histone deacetylases,Inhibitor,inhibit,HDAC,HDAC8 IN 1
  • HDAC8-IN-1(22d)
  • (E)-N-Hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide
  • (2E)-3-(2-{[1,1'-biphenyl]-4-yl}-4-methoxyphenyl)-N-hydroxyprop-2-enamide
  • 1417997-93-3
  • 417997-93-3