ChemicalBook > CAS DataBase List > (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide

(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide

Product Name
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
CAS No.
1417997-93-3
Chemical Name
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
Synonyms
22d;HDAC8-IN-1;CS-2693;MDK-7933;INVIVO-7933;HDAC8-IN-22d;HDAC8-IN-1(22d);HDAC8 inhibitor 1;HDAC8 inhibitor 22d;HDAC8-IN-1 ,MDK7933
CBNumber
CB23373154
Molecular Formula
C22H19NO3
Formula Weight
345.39
MOL File
1417997-93-3.mol
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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Property

Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
pka
8.76±0.23(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28832
Product name
HDAC8-IN-1
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
28832
Product name
HDAC8-IN-1
Packaging
25mg
Price
$692
Updated
2024/03/01
Cayman Chemical
Product number
28832
Product name
HDAC8-IN-1
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
28832
Product name
HDAC8-IN-1
Packaging
10mg
Price
$321
Updated
2024/03/01
TRC
Product number
H805220
Product name
(2E)-N-Hydroxy-3-(5-methoxy[1,1'':4'',1''''-terphenyl]-2-yl)-2-propenamide
Packaging
5mg
Price
$275
Updated
2021/12/16
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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Chemical Properties,Usage,Production

Description

HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8; IC50 = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC50s = ≥3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC50s = 7.9, 7.2, and 7 μM, respectively).

Uses

(2E)-N-Hydroxy-3-(5-methoxy[1,1'':4'',1''''-terphenyl]-2-yl)-2-propenamide, is a HDAC8 inhibitor with an IC50 of 27.2 nM.

(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Suppliers

China 61 United States 7 Global 68
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1417997-93-3, (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamideRelated Search:

3-Piperidinecarboxamide, N-methyl-N-(phenylmethyl)-1-[[4-(trifluoromethyl)phenyl]methyl]-, hydrochloride (1:1) N-benzyl-N-Methyl-1-(4-(trifluoroMethyl)benzyl)piperidine-3-carboxaMide

  • (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
  • HDAC8-IN-1
  • HDAC8-IN-1 ,MDK7933
  • MDK-7933
  • HDAC8 inhibitor 1
  • CS-2693
  • HDAC8 inhibitor 22d
  • HDAC8-IN-22d
  • 2-Propenamide, N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-, (2E)-
  • (2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
  • (E)-N-Hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide
  • INVIVO-7933
  • 22d
  • HDAC-8-IN-1,HDAC8IN1,Histone deacetylases,Inhibitor,inhibit,HDAC,HDAC8 IN 1
  • HDAC8-IN-1(22d)
  • (E)-N-Hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide
  • (2E)-3-(2-{[1,1'-biphenyl]-4-yl}-4-methoxyphenyl)-N-hydroxyprop-2-enamide
  • 1417997-93-3
  • 417997-93-3