Mal-PEG4-Val-Cit-PAB-PNP

Product Name: Mal-PEG4-Val-Cit-PAB-PNP
CAS No.: 2112738-09-5
Chemical Name: Mal-PEG4-Val-Cit-PAB-PNP
Synonyms: Mal-PEG4-Val-Cit-PAB-PNP;4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl (4-nitrophenyl) carbonate;4-((17S,20S)-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosan-21-amido)benzyl (4-nitrophenyl) carbonate;L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;4-[[(2S)-5-(Carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[2-[2-(2,5-dioxo-1-pyrrolyl)ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-Nitrophenyl) Carbonate
CBNumber: CB23373644
Molecular Formula: C40H53N7O15
Formula Weight: 871.89
MOL File: 2112738-09-5.mol

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Mal-PEG4-Val-Cit-PAB-PNP Property

storage temp.: -20°C, protect from light
solubility: Soluble in DMSO, DMF
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23668
Product name: Mal-PEG4-Val-Cit-PAB-PNP
Purity: 97%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1210
Product name: Mal-PEG(4)-Val-Cit-PAB-PNP
Packaging: 100mg
Price: $1012.5
Updated: 2021/12/16

Ambeed

Product number: A763179
Product name: 4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl(4-nitrophenyl)carbonate
Purity: 95%
Packaging: 100mg
Price: $1242
Updated: 2021/12/16

Ambeed

Product number: A763179
Product name: 4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl(4-nitrophenyl)carbonate
Purity: 95%
Packaging: 250mg
Price: $2110
Updated: 2021/12/16

Ambeed

Product number: A763179
Product name: 4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl(4-nitrophenyl)carbonate
Purity: 95%
Packaging: 1g
Price: $5485
Updated: 2021/12/16

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Mal-PEG4-Val-Cit-PAB-PNP Chemical Properties,Usage,Production

Description

Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG space improve compound's aqueous solubility. PNP is a good leaving group.

Biological Activity

Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

Mal-PEG4-Val-Cit-PAB-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

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Mal-PEG4-Val-Cit-PAB-PNP Suppliers

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View Lastest Price from Mal-PEG4-Val-Cit-PAB-PNP manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Mal-PEG4-Val-Cit-PAB-PNP 2112738-09-5
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-03-29

2112738-09-5, Mal-PEG4-Val-Cit-PAB-PNPRelated Search:

Mal-PEG5-CH2CH2Mal Mal-PEG4-Val-Cit-PAB-OH 1-(14-Hydroxy-3,6,9,12-tetraoxatetradecyl)-1H-pyrrole-2,5-dione Mal-PEG4-amine TFA salt 1,1'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis(1H-pyrrole-2,5-dione) Mal-PEG5-amine TFA salt

Mal-PEG4-Val-Cit-PAB-PNP

L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl (4-nitrophenyl) carbonate

4-((17S,20S)-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosan-21-amido)benzyl (4-nitrophenyl) carbonate

4-[[(2S)-5-(Carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[2-[2-(2,5-dioxo-1-pyrrolyl)ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-Nitrophenyl) Carbonate

2112738-09-5

C40H53N7O15

Linker

ADC LINKER