Mal-PEG4-Val-Cit-PAB-OH

Product Name: Mal-PEG4-Val-Cit-PAB-OH
CAS No.: 2055041-39-7
Chemical Name: Mal-PEG4-Val-Cit-PAB-OH
Synonyms: Mal-PEG4-Val-Cit-PAB-OH;L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
CBNumber: CB93373643
Molecular Formula: C33H50N6O11
Formula Weight: 706.78
MOL File: 2055041-39-7.mol

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Mal-PEG4-Val-Cit-PAB-OH Property

Boiling point:: 973.9±65.0 °C(Predicted)
Density: 1.269±0.06 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: 13.41±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23204
Product name: Mal-PEG4-Val-Cit-PAB-OH
Purity: 96%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

BroadPharm

Product number: BP-23204
Product name: Mal-PEG4-Val-Cit-PAB-OH
Purity: 96%
Packaging: 100mg
Price: $680
Updated: 2021/12/16

BroadPharm

Product number: BP-23204
Product name: Mal-PEG4-Val-Cit-PAB-OH
Purity: 96%
Packaging: 250mg
Price: $980
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1200
Product name: Mal-PEG(4)-Val-Cit-PAB
Packaging: 250mg
Price: $1350
Updated: 2021/12/16

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Mal-PEG4-Val-Cit-PAB-OH Chemical Properties,Usage,Production

Description

Mal-PEG4-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved by Cathepsin B. The maleimide group is reactive toward thiol groups between pH 6.5 to 7.5. PEG4 arm increases the aqueous solubility of the compound.

Uses

Mal-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Mal-PEG4-Val-Cit-PAB-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Mal-PEG4-Val-Cit-PAB-OH Suppliers

China 29 United States 4 Global 33

Chengdu Pukang Biotechnology Co., Ltd

Tel: +86-028-82550498 +86-19102685862
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Beijing Jin Ming Biotechnology Co., Ltd.

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Fax: 010-60605840
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Xi'an Confluore Biological Technology Co., Ltd.

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Email: 1924344760@qq.com
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Hangzhou Peptidego Biotech Co.,Ltd.

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Abydos Scientific

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Hangzhou Huarong Pharm Co., Ltd.

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Nanchang Tianzhen Biotechnology Co., Ltd

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csynbio

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View Lastest Price from Mal-PEG4-Val-Cit-PAB-OH manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Mal-PEG4-Val-Cit-PAB-OH 2055041-39-7
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-03-29

2055041-39-7, Mal-PEG4-Val-Cit-PAB-OHRelated Search:

Mal-PEG5-CH2CH2Mal 1-(14-Hydroxy-3,6,9,12-tetraoxatetradecyl)-1H-pyrrole-2,5-dione Mal-PEG4-amine TFA salt 1,1'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis(1H-pyrrole-2,5-dione) Mal-PEG5-amine TFA salt Mal-PEG4-Val-Cit-PAB-PNP

Mal-PEG4-Val-Cit-PAB-OH

L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

2055041-39-7

C33H50N6O11

PROTAC LINKER

ADC LINKER