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MELK-T1(JNJ-47117096) HCl

Product Name
MELK-T1(JNJ-47117096) HCl
CAS No.
1610536-69-0
Chemical Name
MELK-T1(JNJ-47117096) HCl
Synonyms
MELK-T1 HCl;MELK-T1 HCl salt;JNJ-47117096 hcl;MELK-T1 HYDROCHLORIDE;MELK-T1(JNJ-47117096) HCl;JNJ-47117096 hydrochloride;JNJ 47117096 hydrochloride,JNJ47117096 hydrochloride
CBNumber
CB23374494
Molecular Formula
C21H23ClN4O2
Formula Weight
398.89
MOL File
1610536-69-0.mol
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MELK-T1(JNJ-47117096) HCl Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 250 mg/mL (626.74 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0011272
Product name
JNJ-47117096hydrochloride
Purity
99.40%
Packaging
5mg
Price
$330
Updated
2021/12/16
ChemScene
Product number
CS-0011272
Product name
JNJ-47117096hydrochloride
Purity
99.40%
Packaging
10mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0011272
Product name
JNJ-47117096hydrochloride
Purity
99.40%
Packaging
25mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0011272
Product name
JNJ-47117096hydrochloride
Purity
99.40%
Packaging
50mg
Price
$1700
Updated
2021/12/16
ChemScene
Product number
CS-0011272
Product name
JNJ-47117096hydrochloride
Purity
99.40%
Packaging
100mg
Price
$2700
Updated
2021/12/16
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MELK-T1(JNJ-47117096) HCl Chemical Properties,Usage,Production

Biological Activity

MELK-T1(JNJ-47117096) HCl is a potent and selective MELK inhibitor with IC50 value of 23 nM; it also has strong effect on Flt3 with IC50 value of 18 nM.

in vitro

MELK-T1(JNJ-47117096) HCl is potent and selective MELK inhibitor, with an IC 50 of 23 nM, also effectively inhibits Flt3, with an IC 50 of 18 nM, and slighitly blocks CAMKIIδ, Mnk2, CAMKIIγ, and MLCK (IC 50 , 810 nM, 760 nM, 1000 nM, 1000 nM). It suppresses the proliferation of Flt3 -driven Ba/F3 cell lines, with an IC 50 of 1.5 μM in the absence of IL-3, while no inhibitory activity is observed in the presence of IL-3. It does not inhibit the proliferation of Ba/F3 cell lines transfected with either FGFR1, FGFR3, or KDR, either in the presence or absence of IL-3. JNJ-47117096 (MELK-T1, 10 μM) delays the progression of MCF-7 cells through S -phase. JNJ-47117096 inhibits MELK, and then exerts stalled replication forks and DNA double-strand breaks (DSBs). JNJ-47117096 activates the ATM-mediated DNA-damage response (DDR). JNJ-47117096 (3, 10 μM) results in a growth arrest and a senescent phenotype. Moreover, JNJ-47117096 induces a strong phosphorylation of p53, a prolonged up-regulation of p21 and a down-regulation of FOXM1 target genes.

target

IC50: 23 nM (MELK), 18 nM (Flt3)

MELK-T1(JNJ-47117096) HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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MELK-T1(JNJ-47117096) HCl Suppliers

China 17 United States 4 Global 21
TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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32161
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TargetMol Chemicals Inc.
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Email
support@targetmol.com
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United States
ProdList
38631
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Aladdin Scientific
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tp@aladdinsci.com
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United States
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52924
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MedChemExpress
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Email
sales@medchemexpress.com
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United States
ProdList
6398
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1610536-69-0, MELK-T1(JNJ-47117096) HClRelated Search:


  • MELK-T1(JNJ-47117096) HCl
  • JNJ-47117096 hydrochloride
  • MELK-T1 HCl
  • MELK-T1 HYDROCHLORIDE
  • JNJ-47117096 hcl
  • JNJ 47117096 hydrochloride,JNJ47117096 hydrochloride
  • MELK-T1 HCl salt
  • 1610536-69-0