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Selective PI3Kδ Inhibitor 1

Product Name
Selective PI3Kδ Inhibitor 1
CAS No.
2088525-31-7
Chemical Name
Selective PI3Kδ Inhibitor 1
Synonyms
PI3Kδ-IN-5;compound 7n;PI3Kδ-IN-7n;PI3K delta-IN-7n;SelectivePI3KδInhibitor1;Selective PI3Kδ Inhibitor 1;SelectivePI3KδInhibitor1(compound7n);SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N;Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-;Inhibitor,inhibit,Phosphoinositide 3-kinase,PI3K,Selective PI3Kδ Inhibitor 1,Selective PI-3Kδ Inhibitor 1
CBNumber
CB23379666
Molecular Formula
C23H20FN7O
Formula Weight
429.45
MOL File
2088525-31-7.mol
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Selective PI3Kδ Inhibitor 1 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 43 mg/mL (100.13 mM);Ethanol: Insoluble
Water Solubility 
Water: Insoluble
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Hazard and Precautionary Statements (GHS)

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Selective PI3Kδ Inhibitor 1 Chemical Properties,Usage,Production

Biological Activity

Selective PI3Kδ Inhibitor 1 (compound 7n) is a PI3Kδ inhibitor with IC50 of 0.9 nM for PI3Kδ, which is more than 1000-fold selective for other class I PI3K isoforms. The IC50 values of it for PI3Kα/γ/β were 3670, 1460, and 21300 nM, respectively.

in vivo

Selective PI3Kδ Inhibitor 1 has favorable pharmacokinetic profile: good bioavailability and moderate in vivo half-life. In rats, its oral bioavailability was 41%; after intravenous injection, Vss, T 1/2 and CL were 2.8 L/kg, 3.4 h and 12 mL/min/kg, respectively .

target

TargetValue
PI3Kδ
(Cell-free assay)
0.9 nM

Selective PI3Kδ Inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Selective PI3Kδ Inhibitor 1 Suppliers

Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

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