ChemicalBook > CAS DataBase List > LXH254,LXH-254

LXH254,LXH-254

Product Name
LXH254,LXH-254
CAS No.
1800398-38-2
Chemical Name
LXH254,LXH-254
Synonyms
LXH254;Naporafenib;LXH254,LXH-254;LXH254 (NAPORAFENIB);LXH254, 10 mM in DMSO;Naporafenib (LXH-254);LXH254; LXH-254; LXH 254;N-[3-[2-(2-Hydroxyethoxy)-6-morpholino-4-pyridyl]-4-methylphenyl]-2-(trifluoromethyl)isonicotinamide;N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide;N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide?, LXH254
CBNumber
CB23380035
Molecular Formula
C25H25F3N4O4
Formula Weight
502.49
MOL File
1800398-38-2.mol
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LXH254,LXH-254 Property

Boiling point:
601.9±55.0 °C(Predicted)
Density 
1.353±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);199.0(Max Conc. mM)
form 
A crystalline solid
pka
10.86±0.70(Predicted)
color 
Off-white to light yellow
InChIKey
UEPXBTCUIIGYCY-UHFFFAOYSA-N
SMILES
C1(C(F)(F)F)=NC=CC(C(NC2=CC=C(C)C(C3C=C(N4CCOCC4)N=C(OCCO)C=3)=C2)=O)=C1
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28231
Product name
LXH254
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
28231
Product name
LXH254
Packaging
25mg
Price
$819
Updated
2024/03/01
Cayman Chemical
Product number
28231
Product name
LXH254
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
28231
Product name
LXH254
Packaging
10mg
Price
$477
Updated
2024/03/01
TRC
Product number
L395010
Product name
LXH254
Packaging
25mg
Price
$1945
Updated
2021/12/16
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LXH254,LXH-254 Chemical Properties,Usage,Production

Uses

LXH254, is a kinase inhibitor used in the treatment of solid tumors.

in vivo

Treatment with Naporafenib (Compound A) generates tumor regression in several KRAS-mutant models including the NSCLC-derived Calu-6 (KRAS Q61K) and NCI-H358 (KRAS G12C). Naporafenib exhibits efficacy in numerous MAPK-driven human cancer cell lines and in xenograft tumors representing model tumors harboring human lesions in KRAS, NRAS and BRAF oncogenes[1].
Naporafenib shows significant antitumor activity in models harboring BRAF mutations either alone or coincident with either activated NRAS or KRAS, and RAS mutants lacking ARAF are more sensitive to Naporafenib[2].

Animal Model:Outbred athymic (nu/nu) female mice and SCID Beige mice; BRAF-, NRAS-, and KRAS-mutant xenograft models, as well as a RAS/RAF wild-type model[2]
Dosage:100 mg/kg
Administration:Orally, daily
Result:Significantly decreased tumor volume in models harboring BRAF mutations either alone or coincident with either activated NRAS or KRAS, slightly decreased tumor volume in KRAS model.

IC 50

CRAF: 0.072 nM (IC50); Braf: 0.21 nM (IC50); ARAF: 6.4 nM (IC50); p38α: 2.1 μM (IC50); Abl1: 4.9 μM (IC50)

LXH254,LXH-254 Preparation Products And Raw materials

Raw materials

Preparation Products

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LXH254,LXH-254 Suppliers

China 79 India 1 United States 5 Global 85
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
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960
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58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai XingMo Biotechnology Co., Ltd.
Tel
+86 13524779951; 13524779951
Fax
QQ: 2075692521
Email
2075692521@qq.com
Country
China
ProdList
310
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2989
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58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
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58

1800398-38-2, LXH254,LXH-254Related Search:


  • LXH254; LXH-254; LXH 254
  • LXH254,LXH-254
  • LXH254
  • 4-Pyridinecarboxamide, N-[3-[2-(2-hydroxyethoxy)-6-(4-morpholinyl)-4-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)-
  • Naporafenib
  • Bcr-Abl,A375,Inhibitor,p38 MAPK,LXH 254,inhibit,Raf,Mia PaCa-2,Raf kinases,HCT116,LXH254,Selective,MEL-JUSO,LXH-254
  • N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide
  • Naporafenib (LXH-254)
  • N-[3-[2-(2-Hydroxyethoxy)-6-morpholino-4-pyridyl]-4-methylphenyl]-2-(trifluoromethyl)isonicotinamide
  • LXH254 (NAPORAFENIB)
  • LXH254, 10 mM in DMSO
  • N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide?, LXH254
  • 1800398-38-2
  • C25H25F3N4O4