N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
- Product Name
- N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
- CAS No.
- 1052147-86-0
- Chemical Name
- N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
- Synonyms
- LP21;LP-211;LP-211 >=98% (HPLC);LP-211; LP 211; LP211;1052147-86-0;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-;LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
- CBNumber
- CB23385434
- Molecular Formula
- C30H34N4O
- Formula Weight
- 466.62
- MOL File
- 1052147-86-0.mol
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Property
- Boiling point:
- 714.8±60.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM) - pka
- 15.39±0.46(Predicted)
- form
- solid
- color
- clear white to light brown
N-Bromosuccinimide Price
- Product number
- SML1561
- Product name
- LP-211
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $131
- Updated
- 2023/06/20
- Product number
- SML1561
- Product name
- LP-211
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $530
- Updated
- 2023/06/20
- Product number
- 29659
- Product name
- LP-211
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29659
- Product name
- LP-211
- Packaging
- 25mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- 29659
- Product name
- LP-211
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $243
- Updated
- 2024/03/01
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Chemical Properties,Usage,Production
Uses
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity.
Biochem/physiol Actions
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Preparation Products And Raw materials
Raw materials
Preparation Products
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