ChemicalBook > CAS DataBase List > E3 ligase Ligand-Linker Conjugates 3
E3 ligase Ligand-Linker Conjugates 3
- Product Name
- E3 ligase Ligand-Linker Conjugates 3
- CAS No.
- 2101200-09-1
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 3
- Synonyms
- VH032-PEG1-N3;(S,R,S)-AHPC-PEG1-azide;VHL Ligand-Linker Conjugates 9;(S,R,S)-AHPC-PEG1-N3, 10 mM in DMSO;E3 ligase Ligand-Linker Conjugates 3;E3 Ligase Ligand-Linker Conjugates,(S,R,S) AHPC PEG1 N3,Inhibitor,(S,R,S)-AHPC-PEG-1-N3,(S,R,S)AHPCPEG1N3,inhibit;L-Prolinamide, N-[2-(2-azidoethoxy)acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(2-(2-azidoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- CBNumber
- CB23386471
- Molecular Formula
- C26H35N7O5S
- Formula Weight
- 557.67
- MOL File
- 2101200-09-1.mol
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E3 ligase Ligand-Linker Conjugates 3 Property
- storage temp.
- 2-8°C
- form
- Solid
- color
- White to light yellow
- InChIKey
- YVCURZJBLHZABY-ZRCGQRJVSA-N
- SMILES
- O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCN=[N+]=[N-])=O)=O
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Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 903957
- Product name
- (S,R,S)-AHPC-PEG1-azide
- Packaging
- 50mg
- Price
- $373.1
- Updated
- 2025/07/31
Iris Biotech GmbH
- Product number
- PTC1590
- Product name
- (S,R,S)-AHPC-PEG1-N3
- Packaging
- 50mg
- Price
- $634.5
- Updated
- 2021/12/16
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E3 ligase Ligand-Linker Conjugates 3 Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
reaction suitability
reaction type: click chemistry
reagent type: ligand-linker conjugate
IC 50
VHL
E3 ligase Ligand-Linker Conjugates 3 Preparation Products And Raw materials
Raw materials
Preparation Products
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E3 ligase Ligand-Linker Conjugates 3 Suppliers
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 3 manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- (S,R,S)-AHPC-PEG1-azide 2101200-09-1
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >98.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01