1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE

Product Name: 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE
CAS No.: 207857-15-6
Chemical Name: 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE
Synonyms: Goodman's Reagent;1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)-;N N'-BIS(TERT-BUTOXYCARBONYL)-N -TRIFLY&;1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDIN;1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE;n,n'-bis(tert-butoxycarboyl)-n''-trifylguanidine;1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine;N,N'-BIS(TERT-BUTOXYCARBONYL)-N''-TRIFLYLGUANIDINE;1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine ,98%;1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine (~90%)
CBNumber: CB2339467
Molecular Formula: C12H20F3N3O6S
Formula Weight: 391.36
MOL File: 207857-15-6.mol

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1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE Property

Melting point:: 113 °C (dec.)(lit.)
Density: 1.36
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Acetonitrile, Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: -4.76±0.40(Predicted)
color: White to Off-White
BRN: 7947176
InChI: InChI=1S/C12H20F3N3O6S/c1-10(2,3)23-8(19)16-7(17-9(20)24-11(4,5)6)18-25(21,22)12(13,14)15/h1-6H3,(H2,16,17,18,19,20)
InChIKey: GOQZIPJCBUYLIR-UHFFFAOYSA-N
SMILES: C(/NC(=O)OC(C)(C)C)(=N\C(=O)OC(C)(C)C)\NS(=O)(=O)C(F)(F)F

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-21
HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15033
Product name: 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine
Purity: ≥95.0% (HPLC)
Packaging: 1g
Price: $125
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15033
Product name: 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine
Purity: ≥95.0% (HPLC)
Packaging: 5g
Price: $533
Updated: 2025/07/31

TRC

Product number: D422740
Product name: 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine(~90%)
Packaging: 1g
Price: $180
Updated: 2021/12/16

TRC

Product number: D422740
Product name: 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine(~90%)
Packaging: 250mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD49815
Product name: 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine
Packaging: 1g
Price: $100
Updated: 2021/12/16

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1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine is a guanidinylation reagent for amines and peptides.

Synthesis

358-23-6

332882-82-3

207857-15-6

N,N'-Bis(tert-butoxycarbonyl)guanidine (S6; 4.38 g, 16.9 mmol, 1.00 eq.) was dissolved in dichloromethane (CH2Cl2, 84.4 mL) at room temperature. The reaction mixture was cooled to -78°C and stirred for 10 minutes. Subsequently, freshly distilled triethylamine (Et3N; 1.79 g, 17.7 mmol, 1.05 eq.) was added slowly and dropwise. Trifluoromethanesulfonic anhydride (5.00 g, 17.7 mmol, 1.05 eq.) was added dropwise over 15 min at -78 °C while maintaining vigorous stirring. The reaction mixture was gradually warmed up to room temperature. After 6 hours of reaction, the reaction mixture was washed with 1.0 M potassium bisulfate (KHSO4) solution followed by water (H2O). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and filtered. The solvent was removed by concentration under reduced pressure. Purification by silica gel fast column chromatography (eluent: 100% dichloromethane) afforded 1,3-di-BOC-2-(trifluoromethylsulfonyl)guanidine (S7; 5.51 g, 14.1 mmol, 83% yield) as a colorless solid.

References

[1] Journal of Organic Chemistry, 2001, vol. 66, # 3, p. 1038 - 1042
[2] Organic Syntheses, 2002, vol. 78, p. 91 - 91
[3] Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 3804 - 3805
[4] Journal of Organic Chemistry, 1998, vol. 63, # 23, p. 8432 - 8439
[5] ChemMedChem, 2014, vol. 9, # 1, p. 129 - 150

1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE Suppliers

Belgium 1 China 114 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 2 United States 9 Global 135

Shenzhen Chim Biotech Co., Ltd.

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View Lastest Price from 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE manufacturers

Shaanxi Didu New Materials Co. Ltd

Product: 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE 207857-15-6
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-09-25

Hubei Lidu New Material Technology Co., Ltd

Product: 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE 207857-15-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20 tons
Release date: 2025-07-23

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE 207857-15-6
Price: US $0.10-0.30/kg
Min. Order: 1kg
Purity: 95%
Supply Ability: 20 tons
Release date: 2024-01-20

207857-15-6, 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINERelated Search:

1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE BOC-GUANIDINE 1 3-BIS(TERT-BUTOXYCARBONYL)GUANIDINE METHYLENE DIURETHANE

tert-butyl N-({[(tert-butoxy)carbonyl]amino}(trifluoromethanesulfonylimino)methyl)carbamate

N,N'-BIS(TERT-BUTOXYCARBONYL)-N''-TRIFLYLGUANIDINE

1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE

N N'-BIS(TERT-BUTOXYCARBONYL)-N -TRIFLY&

1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)-

n,n'-bis(tert-butoxycarboyl)-n''-trifylguanidine

1,3-Bis(tert-butoxycarbonyl)-2-(trifluoroMethanesulfonyl)guanidine (This product is only available for selling doMestically in Japan)

2-[(Trifluoromethyl)sulphonyl]guanidine, 1,3-Bis-BOC protected

tert-Butyl {N-(tert-butoxycarbonyl)-N'-[(trifluoromethyl)sulphonyl]carbamimidoyl}carbamate

N,N'-Bis(1,1-dimethylethoxycarbonyl)-N''-(trifluoromethylsulfonyl)guanidine

N,N'-Bis(tert-butoxycarbonyl)-N''-(trifluoromethanesulfonyl)guanidine

1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine

1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine 1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine Goodman's Reagent

1,3-Di-Boc-2-(trifluoroMethylsulfonyl)guanidine,>=95.0%(HPLC)

dimethylethoxycarbonyl)-N''-(trifluoromethylsulfonyl)guanidine

1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine ,98%

1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

2-[(Trifluoromethyl)sulphonyl]guanidine, 1,3-Bis-BOC protected 95%

tert-butyl {(tert-butoxycarbonyl)[(trifluoromethyl)sulfonyl]carbamimidoyl}carbamate (non-preferred name)

tert-Butyl [(tert-butoxycarbonyl)amino]{[(trifluoro-methyl)sulfonyl]imino}methylcarbamate

1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine (This product is only available in Japan.)

Carbamic acid, [[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-, bis(1,1-dimethylethyl)ester

1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine≥ 98% (HPLC)

Tert-Butyl N-[N-tert-butoxycarbonyl-N'-(trifluoromethylsulfonyl)

1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine (~90%)

Carbamic acid, N,N'-[[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-, C,C'-bis(1,1-dimethylethyl) ester

tert-Butyl N-N-tert-butoxycarbonyl-N'-(trifluoromethylsulfonyl)carbamimidoylcarbamate

ert-butylN-[N-[(2-methylpropan-2-yl)oxycarbonyl]-N'-(trifluoromethylsulfonyl)carbamimidoyl]carbamate

1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine

Goodman's Reagent

tert-butyl {(tert-butoxycarbonyl)[(trifluoromethyl)sulfonyl]...

tert-butyl N-[(tert-butoxycarbonylamino)-(trifluoromethylsulfonylamino)methylene]carbamate

1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDIN

207857-15-6

207837-15-6

CF3SO2NCNHCO2CCH332

C12H20F3N3O6S

Peptide Synthesis

Specialty Synthesis

Guanidine Protection/Guanidinylation