ChemicalBook > CAS DataBase List > 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE

1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE

Product Name
1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE
CAS No.
207857-15-6
Chemical Name
1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE
Synonyms
Goodman's Reagent;1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)-;N N'-BIS(TERT-BUTOXYCARBONYL)-N -TRIFLY&;1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDIN;1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE;n,n'-bis(tert-butoxycarboyl)-n''-trifylguanidine;1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine;N,N'-BIS(TERT-BUTOXYCARBONYL)-N''-TRIFLYLGUANIDINE;1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine ,98%;1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine (~90%)
CBNumber
CB2339467
Molecular Formula
C12H20F3N3O6S
Formula Weight
391.36
MOL File
207857-15-6.mol
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1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE Property

Melting point:
113 °C (dec.)(lit.)
Density 
1.36
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Acetonitrile, Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
form 
Solid
pka
-4.76±0.40(Predicted)
color 
White to Off-White
BRN 
7947176
InChI
InChI=1S/C12H20F3N3O6S/c1-10(2,3)23-8(19)16-7(17-9(20)24-11(4,5)6)18-25(21,22)12(13,14)15/h1-6H3,(H2,16,17,18,19,20)
InChIKey
GOQZIPJCBUYLIR-UHFFFAOYSA-N
SMILES
C(/NC(=O)OC(C)(C)C)(=N\C(=O)OC(C)(C)C)\NS(=O)(=O)C(F)(F)F
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-21
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15033
Product name
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine
Purity
≥95.0% (HPLC)
Packaging
1g
Price
$125
Updated
2025/07/31
Sigma-Aldrich
Product number
15033
Product name
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine
Purity
≥95.0% (HPLC)
Packaging
5g
Price
$533
Updated
2025/07/31
TRC
Product number
D422740
Product name
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine(~90%)
Packaging
1g
Price
$180
Updated
2021/12/16
TRC
Product number
D422740
Product name
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine(~90%)
Packaging
250mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD49815
Product name
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine
Packaging
1g
Price
$100
Updated
2021/12/16
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1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine is a guanidinylation reagent for amines and peptides.

Synthesis

358-23-6

332882-82-3

207857-15-6

N,N'-Bis(tert-butoxycarbonyl)guanidine (S6; 4.38 g, 16.9 mmol, 1.00 eq.) was dissolved in dichloromethane (CH2Cl2, 84.4 mL) at room temperature. The reaction mixture was cooled to -78°C and stirred for 10 minutes. Subsequently, freshly distilled triethylamine (Et3N; 1.79 g, 17.7 mmol, 1.05 eq.) was added slowly and dropwise. Trifluoromethanesulfonic anhydride (5.00 g, 17.7 mmol, 1.05 eq.) was added dropwise over 15 min at -78 °C while maintaining vigorous stirring. The reaction mixture was gradually warmed up to room temperature. After 6 hours of reaction, the reaction mixture was washed with 1.0 M potassium bisulfate (KHSO4) solution followed by water (H2O). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and filtered. The solvent was removed by concentration under reduced pressure. Purification by silica gel fast column chromatography (eluent: 100% dichloromethane) afforded 1,3-di-BOC-2-(trifluoromethylsulfonyl)guanidine (S7; 5.51 g, 14.1 mmol, 83% yield) as a colorless solid.

References

[1] Journal of Organic Chemistry, 2001, vol. 66, # 3, p. 1038 - 1042
[2] Organic Syntheses, 2002, vol. 78, p. 91 - 91
[3] Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 3804 - 3805
[4] Journal of Organic Chemistry, 1998, vol. 63, # 23, p. 8432 - 8439
[5] ChemMedChem, 2014, vol. 9, # 1, p. 129 - 150

1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE Suppliers

Belgium 1 China 114 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 2 United States 9 Global 135
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE manufacturers

Shaanxi Didu New Materials Co. Ltd
Product
1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE 207857-15-6
Price
US $1.50/g
Min. Order
1g
Purity
99.0% Min
Supply Ability
100 Tons
Release date
2025-09-25
Hubei Lidu New Material Technology Co., Ltd
Product
1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE 207857-15-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20 tons
Release date
2025-07-23
Zibo Hangyu Biotechnology Development Co., Ltd
Product
1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE 207857-15-6
Price
US $0.10-0.30/kg
Min. Order
1kg
Purity
95%
Supply Ability
20 tons
Release date
2024-01-20

207857-15-6, 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINERelated Search:

1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE BOC-GUANIDINE 1 3-BIS(TERT-BUTOXYCARBONYL)GUANIDINE METHYLENE DIURETHANE

  • tert-butyl N-({[(tert-butoxy)carbonyl]amino}(trifluoromethanesulfonylimino)methyl)carbamate
  • N,N'-BIS(TERT-BUTOXYCARBONYL)-N''-TRIFLYLGUANIDINE
  • 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE
  • N N'-BIS(TERT-BUTOXYCARBONYL)-N -TRIFLY&
  • 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)-
  • n,n'-bis(tert-butoxycarboyl)-n''-trifylguanidine
  • 1,3-Bis(tert-butoxycarbonyl)-2-(trifluoroMethanesulfonyl)guanidine (This product is only available for selling doMestically in Japan)
  • 2-[(Trifluoromethyl)sulphonyl]guanidine, 1,3-Bis-BOC protected
  • tert-Butyl {N-(tert-butoxycarbonyl)-N'-[(trifluoromethyl)sulphonyl]carbamimidoyl}carbamate
  • N,N'-Bis(1,1-dimethylethoxycarbonyl)-N''-(trifluoromethylsulfonyl)guanidine
  • N,N'-Bis(tert-butoxycarbonyl)-N''-(trifluoromethanesulfonyl)guanidine
  • 1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine
  • 1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine 1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine Goodman's Reagent
  • 1,3-Di-Boc-2-(trifluoroMethylsulfonyl)guanidine,>=95.0%(HPLC)
  • dimethylethoxycarbonyl)-N''-(trifluoromethylsulfonyl)guanidine
  • 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine ,98%
  • 1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
  • 2-[(Trifluoromethyl)sulphonyl]guanidine, 1,3-Bis-BOC protected 95%
  • tert-butyl {(tert-butoxycarbonyl)[(trifluoromethyl)sulfonyl]carbamimidoyl}carbamate (non-preferred name)
  • tert-Butyl [(tert-butoxycarbonyl)amino]{[(trifluoro-methyl)sulfonyl]imino}methylcarbamate
  • 1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine (This product is only available in Japan.)
  • Carbamic acid, [[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-, bis(1,1-dimethylethyl)ester
  • 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine≥ 98% (HPLC)
  • Tert-Butyl N-[N-tert-butoxycarbonyl-N'-(trifluoromethylsulfonyl)
  • 1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine (~90%)
  • Carbamic acid, N,N'-[[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-, C,C'-bis(1,1-dimethylethyl) ester
  • tert-Butyl N-N-tert-butoxycarbonyl-N'-(trifluoromethylsulfonyl)carbamimidoylcarbamate
  • ert-butylN-[N-[(2-methylpropan-2-yl)oxycarbonyl]-N'-(trifluoromethylsulfonyl)carbamimidoyl]carbamate
  • 1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine
  • Goodman's Reagent
  • tert-butyl {(tert-butoxycarbonyl)[(trifluoromethyl)sulfonyl]...
  • tert-butyl N-[(tert-butoxycarbonylamino)-(trifluoromethylsulfonylamino)methylene]carbamate
  • 1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDIN
  • 207857-15-6
  • 207837-15-6
  • CF3SO2NCNHCO2CCH332
  • C12H20F3N3O6S
  • Peptide Synthesis
  • Specialty Synthesis
  • Guanidine Protection/Guanidinylation