THIODIGALACTOSIDE
- Product Name
- THIODIGALACTOSIDE
- CAS No.
- 51555-87-4
- Chemical Name
- THIODIGALACTOSIDE
- Synonyms
- TDG;THIODIGALACTOSIDE;Thiodigalactoside - Bio-X ?;Galactosyl 1-thiogalactoside;Thiodigalactoside, 10 mM in DMSO;D-Galactopyranosyl-b-D-thiogalactopyranoside;d-galactopyranosyl-β-d-thiogalactopyranoside;D-GALACTOPYRANOSYL BETA-D-THIOGALACTOPYRANOSIDE;D-Galactopyranosyl-β-D-thiogalactopyranoside ,98%;β-D-Galactopyranoside, β-D-galactopyranosyl 1-thio-
- CBNumber
- CB2340922
- Molecular Formula
- C12H22O10S
- Formula Weight
- 358.36
- MOL File
- 51555-87-4.mol
THIODIGALACTOSIDE Property
- Melting point:
- >225°C (dec.)
- storage temp.
- −20°C
- solubility
- DMSO (Slightly)
- form
- Solid
- color
- White
- Water Solubility
- H2O: 2mg/mL, clear
- InChI
- InChI=1/C12H22O10S/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5+,6+,7+,8+,9-,10-,11+,12?/s3
- InChIKey
- SYKYBMOFPMXDRQ-YSLNCGCNNA-N
- SMILES
- C1([C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O)S[C@H]1[C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O |&1:1,3,4,6,12,13,15,16,18,r|
Safety
- WGK Germany
- 3
- HS Code
- 29389090
N-Bromosuccinimide Price
- Product number
- 17154
- Product name
- Thiodigalactoside
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17154
- Product name
- Thiodigalactoside
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 17154
- Product name
- Thiodigalactoside
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 17154
- Product name
- Thiodigalactoside
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- T344595
- Product name
- Thiodigalactoside
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
THIODIGALACTOSIDE Chemical Properties,Usage,Production
Description
Galectins are a family of glycan-binding lectins with diverse regulatory roles in physiological processes. They have significant roles in inflammation and cancer. Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 μM. It is used to investigate the roles of these galectins in cell signaling and carcinogenesis.
Chemical Properties
White to off-white crystalline powder
Uses
Thiogdigalactosideis an inhibitor of galectin 1 which has an essential role in high-fat diet induced obesity development.
References
[1] ALI HASAN EBRAHIM. Galectins in cancer: carcinogenesis, diagnosis and therapy.[J]. Annals of translational medicine, 2014, 2 9: 88. DOI: 10.3978/j.issn.2305-5839.2014.09.12
[2] NANDOR GABOR THAN. Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia.[J]. Journal of Pathology and Translational Medicine, 2015, 49 3: 181-208. DOI: 10.4132/jptm.2015.02.25
[3] BADER A. SALAMEH . 1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2010, 18 14: Pages 5367-5378. DOI: 10.1016/j.bmc.2010.05.040
[4] HILDE VAN HATTUM. Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1[J]. Journal of Medicinal Chemistry, 2013, 56 3: 1350-1354. DOI: 10.1021/jm301677r
[5] KOICHI ITO. Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress[J]. Angiogenesis, 2011, 14 3: 293-307. DOI: 10.1007/s10456-011-9213-5
[6] PEIWEN KUO. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response.[J]. Clinical Cancer Research, 2014, 20 21: 5558-5569. DOI: 10.1158/1078-0432.ccr-14-1138
[7] R MUKHERJEE. Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[J]. International Journal of Obesity, 2015, 39 9: 1349-1358. DOI: 10.1038/ijo.2015.74
THIODIGALACTOSIDE Preparation Products And Raw materials
Raw materials
Preparation Products
THIODIGALACTOSIDE Suppliers
- Tel
- 0512-66317708 13372112871
- huijuan@zitrans.cn
- Country
- China
- ProdList
- 1993
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 1-516-6625404
- Fax
- 1-516-927-0118
- support@alfa-chemistry.com
- Country
- United States
- ProdList
- 9171
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29760
- Advantage
- 68
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- +1-5166625404;
- Fax
- 1-516-927-0118
- Info@alfa-chemistry.com
- Country
- United States
- ProdList
- 20405
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
View Lastest Price from THIODIGALACTOSIDE manufacturers
- Product
- Thiodigalactoside 51555-87-4
- Price
- US $0.00/G
- Min. Order
- 10G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-13