6-Mercaptohexan-1-ol
- Product Name
- 6-Mercaptohexan-1-ol
- CAS No.
- 1633-78-9
- Chemical Name
- 6-Mercaptohexan-1-ol
- Synonyms
- 6-MERCAPTO-1-HEXANOL;6-MCH;6-MERCAPTOHEXAN-1-OL;1-Hexanol, 6-mercapto-;6-Mercapto-1-hexanol>6-Hydroxy-1-hexanethiol;6-Mercapto-1-hexanol 97%;6-Mercapto-1-hexanol ,97%;6-Hydrosulphonyl-1-Hexanol;6-Hydroxy-1-hexanethiol 6-MCH 6-Mercaptohexan-1-ol 6-Mercaptohexanol MCH
- CBNumber
- CB7778009
- Molecular Formula
- C6H14OS
- Formula Weight
- 134.24
- MOL File
- 1633-78-9.mol
6-Mercaptohexan-1-ol Property
- Boiling point:
- 225 °C(lit.)
- Density
- 0.981 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.486(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- liquid
- pka
- 10.47±0.10(Predicted)
- color
- Colourless
- BRN
- 1846871
- Stability:
- Air Sensitive
- InChI
- InChI=1S/C6H14OS/c7-5-3-1-2-4-6-8/h7-8H,1-6H2
- InChIKey
- UGZAJZLUKVKCBM-UHFFFAOYSA-N
- SMILES
- C(O)CCCCCS
- LogP
- 1.370 (est)
- EPA Substance Registry System
- 1-Hexanol, 6-mercapto- (1633-78-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 451088
- Product name
- 6-Mercapto-1-hexanol
- Purity
- 97%
- Packaging
- 5ml
- Price
- $89.3
- Updated
- 2025/07/31
- Product number
- 451088
- Product name
- 6-Mercapto-1-hexanol
- Purity
- 97%
- Packaging
- 25ml
- Price
- $298
- Updated
- 2025/07/31
- Product number
- M2266
- Product name
- 6-Mercapto-1-hexanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- M2266
- Product name
- 6-Mercapto-1-hexanol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $380
- Updated
- 2025/07/31
- Product number
- 725226
- Product name
- 6-Mercapto-1-hexanol
- Purity
- 99%
- Packaging
- 1g
- Price
- $277
- Updated
- 2025/07/31
6-Mercaptohexan-1-ol Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liquid
Uses
6-Mercapto-1-hexanolcan be used as a chemical linker for anchoring biological molecules to gold surfaces.
Uses
This compound is used to produce hydrophilic SAMs. The resulting monolayers which are terminated with alcohols can be further functionalized with various groups even when attached to gold nanoclusters.
Uses
MCH is coated on a piezoelectric crystal which can be used for the fabrication of chemical sensor to differentiate between cheese varieties. Self assembled monolayers of MCH can be used on gold surfaces for bio-sensing applications. It can also be used as a monolayer for the surface modification of gold-polyaniline (Au-PANI) nanocomposites for the development of aptamer based biosensors (aptasensors).
General Description
6-mecapto-1-hexanol (MCH) forms a self-assembled monolayer (SAM) with identically represented C6 spacer. MCH is a tool for surface coating that enables blocking of active sites and non-specific absorption.
reaction suitability
reagent type: linker
Synthesis
4286-55-9
1633-78-9
The general procedure for the synthesis of 6-mercaptohexan-1-ol from 6-bromohexanol was as follows: 6-bromohexanol (1 g, 5.60 mmol) was mixed with thiourea (0.64 g, 8.40 mmol) and NaOH (0.1 M) in 1,4-dioxane (4 mL), and the reaction was carried out at reflux for 4 hours. After completion of the reaction, the reaction mixture was cooled and the solvent was removed under vacuum. Subsequently, the pH of the reaction mixture was adjusted to 4 by addition of dilute hydrochloric acid. hydrochloric acid and thiol derivatives in the reaction mixture were extracted with dichloromethane. The organic layer was dried with anhydrous sodium sulfate and then concentrated to give 6-mercaptohexan-1-ol as a yellow oil. Yield: 0.563 g (75%). The structure of the product was determined by 1H NMR (500 MHz, DMSO-d6, TMS): δ 3.65 (s, 1H), 3.5 (t, 2H, J = 2.4Hz), 2.56 (t, 2H, J = 2.3Hz), 1.52-1.57 (m, 4H), 1.5 (s, 1H), 1.41-1.44 (m, 4H); 13C NMR ( 125 MHz, DMSO): δ 62.8,34.5,32.3,28.2,24.9,24.6; ESI-MS: m/z calculated values. For C6H14OS: 134.08, measured value: 135.11 (M++1) for confirmation.
References
[1] Journal of Chemical Sciences, 2018, vol. 130, # 10,
[2] Journal of Organic Chemistry, 1999, vol. 64, # 13, p. 4959 - 4961
[3] Chemical Physics Letters, 1997, vol. 264, # 3-4, p. 376 - 380
[4] Chemistry Letters, 1996, # 8, p. 635 - 636
[5] Chemistry Letters, 1996, # 8, p. 635 - 636
6-Mercaptohexan-1-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Mercaptohexan-1-ol manufacturers
- Product
- 6-Mercaptohexan-1-ol 1633-78-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 100kg/week
- Release date
- 2019-08-05